IL36G

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Interleukin 36, gamma
Identifiers
Symbols IL36G ; IL-1F9; IL-1H1; IL-1RP2; IL1E; IL1F9; IL1H1; IL1RP2
External IDs OMIM605542 MGI2449929 HomoloGene49595 GeneCards: IL36G Gene
RNA expression pattern
PBB GE IL1F9 220322 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 56300 215257
Ensembl ENSG00000136688 ENSMUSG00000044103
UniProt Q9NZH8 Q3U0P4
RefSeq (mRNA) NM_019618 NM_153511
RefSeq (protein) NP_062564 NP_705731
Location (UCSC) Chr 2:
113.73 – 113.74 Mb
Chr 2:
24.19 – 24.19 Mb
PubMed search [1] [2]

Interleukin-36 gamma also known as interleukin-1 family member 9 (IL1F9) is a protein that in humans is encoded by the IL36G gene.[1][2][3][4][5]

Function[edit]

The protein encoded by this gene is a member of the interleukin 1 cytokine family. The activity of this cytokine is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta). Interferon-gamma, tumor necrosis factor-alpha and interleukin 1, beta (IL1B) are reported to stimulate the expression of this cytokine in keratinocytes. The expression of this cytokine in keratinocytes can also be induced by a contact hypersensitivity reaction or herpes simplex virus infection. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.[5]

References[edit]

  1. ^ Busfield SJ, Comrack CA, Yu G, Chickering TW, Smutko JS, Zhou H, Leiby KR, Holmgren LM, Gearing DP, Pan Y (Aug 2000). "Identification and gene organization of three novel members of the IL-1 family on human chromosome 2". Genomics 66 (2): 213–6. doi:10.1006/geno.2000.6184. PMID 10860666. 
  2. ^ Kumar S, McDonnell PC, Lehr R, Tierney L, Tzimas MN, Griswold DE, Capper EA, Tal-Singer R, Wells GI, Doyle ML, Young PR (May 2000). "Identification and initial characterization of four novel members of the interleukin-1 family". J Biol Chem 275 (14): 10308–14. doi:10.1074/jbc.275.14.10308. PMID 10744718. 
  3. ^ Nicklin MJ, Barton JL, Nguyen M, FitzGerald MG, Duff GW, Kornman K (May 2002). "A sequence-based map of the nine genes of the human interleukin-1 cluster". Genomics 79 (5): 718–25. doi:10.1006/geno.2002.6751. PMID 11991722. 
  4. ^ Taylor SL, Renshaw BR, Garka KE, Smith DE, Sims JE (May 2002). "Genomic organization of the interleukin-1 locus". Genomics 79 (5): 726–33. doi:10.1006/geno.2002.6752. PMID 11991723. 
  5. ^ a b "Entrez Gene: IL1F9 interleukin 1 family, member 9". 

Further reading[edit]