IL1F9
From Wikipedia, the free encyclopedia
| Interleukin 36, gamma | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | IL36G; IL-1F9; IL-1H1; IL-1RP2; IL1E; IL1F9; IL1H1; IL1RP2 | ||||||||||||
| External IDs | OMIM: 605542 MGI: 2449929 HomoloGene: 49595 GeneCards: IL36G Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 56300 | 215257 | |||||||||||
| Ensembl | ENSG00000136688 | ENSMUSG00000044103 | |||||||||||
| UniProt | Q9NZH8 | Q3U0P4 | |||||||||||
| RefSeq (mRNA) | NM_019618 | NM_153511 | |||||||||||
| RefSeq (protein) | NP_062564 | NP_705731 | |||||||||||
| Location (UCSC) | Chr 2: 113.73 – 113.74 Mb |
Chr 2: 24.19 – 24.19 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Interleukin-1 family member 9 is a protein that in humans is encoded by the IL1F9 gene.[1][2][3][4][5]
The protein encoded by this gene is a member of the interleukin 1 cytokine family. The activity of this cytokine is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta). Interferon-gamma, tumor necrosis factor-alpha and interleukin 1, beta (IL1B) are reported to stimulate the expression of this cytokine in keratinocytes. The expression of this cytokine in keratinocytes can also be induced by a contact hypersensitivity reaction or herpes simplex virus infection. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.[5]
References [edit]
- ^ Busfield SJ, Comrack CA, Yu G, Chickering TW, Smutko JS, Zhou H, Leiby KR, Holmgren LM, Gearing DP, Pan Y (Aug 2000). "Identification and gene organization of three novel members of the IL-1 family on human chromosome 2". Genomics 66 (2): 213–6. doi:10.1006/geno.2000.6184. PMID 10860666.
- ^ Kumar S, McDonnell PC, Lehr R, Tierney L, Tzimas MN, Griswold DE, Capper EA, Tal-Singer R, Wells GI, Doyle ML, Young PR (May 2000). "Identification and initial characterization of four novel members of the interleukin-1 family". J Biol Chem 275 (14): 10308–14. doi:10.1074/jbc.275.14.10308. PMID 10744718.
- ^ Nicklin MJ, Barton JL, Nguyen M, FitzGerald MG, Duff GW, Kornman K (May 2002). "A sequence-based map of the nine genes of the human interleukin-1 cluster". Genomics 79 (5): 718–25. doi:10.1006/geno.2002.6751. PMID 11991722.
- ^ Taylor SL, Renshaw BR, Garka KE, Smith DE, Sims JE (May 2002). "Genomic organization of the interleukin-1 locus". Genomics 79 (5): 726–33. doi:10.1006/geno.2002.6752. PMID 11991723.
- ^ a b "Entrez Gene: IL1F9 interleukin 1 family, member 9".
Further reading [edit]
- Nicklin MJ, Weith A, Duff GW (1994). "A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes.". Genomics 19 (2): 382–4. doi:10.1006/geno.1994.1076. PMID 8188271.
- Nothwang HG, Strahm B, Denich D, et al. (1997). "Molecular cloning of the interleukin-1 gene cluster: construction of an integrated YAC/PAC contig and a partial transcriptional map in the region of chromosome 2q13.". Genomics 41 (3): 370–8. doi:10.1006/geno.1997.4654. PMID 9169134.
- Mulero JJ, Pace AM, Nelken ST, et al. (1999). "IL1HY1: A novel interleukin-1 receptor antagonist gene.". Biochem. Biophys. Res. Commun. 263 (3): 702–6. doi:10.1006/bbrc.1999.1440. PMID 10512743.
- Smith DE, Renshaw BR, Ketchem RR, et al. (2000). "Four new members expand the interleukin-1 superfamily.". J. Biol. Chem. 275 (2): 1169–75. doi:10.1074/jbc.275.2.1169. PMID 10625660.
- Barton JL, Herbst R, Bosisio D, et al. (2001). "A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities.". Eur. J. Immunol. 30 (11): 3299–308. doi:10.1002/1521-4141(200011)30:11<3299::AID-IMMU3299>3.0.CO;2-S. PMID 11093146.
- Pan G, Risser P, Mao W, et al. (2001). "IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp.". Cytokine 13 (1): 1–7. doi:10.1006/cyto.2000.0799. PMID 11145836.
- Lin H, Ho AS, Haley-Vicente D, et al. (2001). "Cloning and characterization of IL-1HY2, a novel interleukin-1 family member.". J. Biol. Chem. 276 (23): 20597–602. doi:10.1074/jbc.M010095200. PMID 11278614.
- Debets R, Timans JC, Homey B, et al. (2001). "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2.". J. Immunol. 167 (3): 1440–6. PMID 11466363.
- Sims JE, Nicklin MJ, Bazan JF, et al. (2001). "A new nomenclature for IL-1-family genes.". Trends Immunol. 22 (10): 536–7. doi:10.1016/S1471-4906(01)02040-3. PMID 11574262.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Towne JE, Garka KE, Renshaw BR, et al. (2004). "Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs". J. Biol. Chem. 279 (14): 13677–88. doi:10.1074/jbc.M400117200. PMID 14734551.
- Dennis RA, Trappe TA, Simpson P, et al. (2005). "Interleukin-1 polymorphisms are associated with the inflammatory response in human muscle to acute resistance exercise". J. Physiol. (Lond.) 560 (Pt 3): 617–26. doi:10.1113/jphysiol.2004.067876. PMC 1665272. PMID 15331687.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Vos JB, van Sterkenburg MA, Rabe KF, et al. (2005). "Transcriptional response of bronchial epithelial cells to Pseudomonas aeruginosa: identification of early mediators of host defense". Physiol. Genomics 21 (3): 324–36. doi:10.1152/physiolgenomics.00289.2004. PMID 15701729.
- Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
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