IL1RAP

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Interleukin 1 receptor accessory protein
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols IL1RAP ; C3orf13; IL-1RAcP; IL1R3
External IDs OMIM602626 MGI104975 HomoloGene1643 GeneCards: IL1RAP Gene
RNA expression pattern
PBB GE IL1RAP 205227 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3556 16180
Ensembl ENSG00000196083 ENSMUSG00000022514
UniProt Q9NPH3 Q61730
RefSeq (mRNA) NM_001167928 NM_001159317
RefSeq (protein) NP_001161400 NP_001152789
Location (UCSC) Chr 3:
190.23 – 190.38 Mb
Chr 16:
26.58 – 26.73 Mb
PubMed search [1] [2]

Interleukin-1 receptor accessory protein is a protein that in humans is encoded by the IL1RAP gene.[1][2][3]

Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes an interleukin 1 receptor accessory protein. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble.[3]

Interactions[edit]

IL1RAP has been shown to interact with TOLLIP[4] and Interleukin 1 receptor, type I.[5]

References[edit]

  1. ^ Dale M, Hammond DW, Cox A, Nicklin MJ (April 1998). "The human gene encoding the interleukin-1 receptor accessory protein (IL1RAP) maps to chromosome 3q28 by fluorescence in situ hybridization and radiation hybrid mapping". Genomics 47 (2): 325–6. doi:10.1006/geno.1997.5113. PMID 9479509. 
  2. ^ Wesche H, Korherr C, Kracht M, Falk W, Resch K, Martin MU (April 1997). "The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases)". J Biol Chem 272 (12): 7727–31. doi:10.1074/jbc.272.12.7727. PMID 9065432. 
  3. ^ a b "Entrez Gene: IL1RAP interleukin 1 receptor accessory protein". 
  4. ^ Burns, K; Clatworthy J; Martin L; Martinon F; Plumpton C; Maschera B; Lewis A; Ray K; Tschopp J; Volpe F (June 2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor". Nat. Cell Biol. (ENGLAND) 2 (6): 346–51. doi:10.1038/35014038. ISSN 1465-7392. PMID 10854325. 
  5. ^ Huang, J; Gao X; Li S; Cao Z (November 1997). "Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (24): 12829–32. doi:10.1073/pnas.94.24.12829. ISSN 0027-8424. PMC 24223. PMID 9371760. 

Further reading[edit]