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Interleukin 1 receptor accessory protein
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols IL1RAP ; C3orf13; IL-1RAcP; IL1R3
External IDs OMIM602626 MGI104975 HomoloGene1643 GeneCards: IL1RAP Gene
RNA expression pattern
PBB GE IL1RAP 205227 at tn.png
More reference expression data
Species Human Mouse
Entrez 3556 16180
Ensembl ENSG00000196083 ENSMUSG00000022514
UniProt Q9NPH3 Q61730
RefSeq (mRNA) NM_001167928 NM_001159317
RefSeq (protein) NP_001161400 NP_001152789
Location (UCSC) Chr 3:
190.23 – 190.38 Mb
Chr 16:
26.58 – 26.73 Mb
PubMed search [1] [2]

Interleukin-1 receptor accessory protein is a protein that in humans is encoded by the IL1RAP gene.[1][2][3]

Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes an interleukin 1 receptor accessory protein. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble.[3]


IL1RAP has been shown to interact with TOLLIP[4] and Interleukin 1 receptor, type I.[5]


  1. ^ Dale M, Hammond DW, Cox A, Nicklin MJ (April 1998). "The human gene encoding the interleukin-1 receptor accessory protein (IL1RAP) maps to chromosome 3q28 by fluorescence in situ hybridization and radiation hybrid mapping". Genomics 47 (2): 325–6. doi:10.1006/geno.1997.5113. PMID 9479509. 
  2. ^ Wesche H, Korherr C, Kracht M, Falk W, Resch K, Martin MU (April 1997). "The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases)". J Biol Chem 272 (12): 7727–31. doi:10.1074/jbc.272.12.7727. PMID 9065432. 
  3. ^ a b "Entrez Gene: IL1RAP interleukin 1 receptor accessory protein". 
  4. ^ Burns, K; Clatworthy J; Martin L; Martinon F; Plumpton C; Maschera B; Lewis A; Ray K; Tschopp J; Volpe F (June 2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor". Nat. Cell Biol. (ENGLAND) 2 (6): 346–51. doi:10.1038/35014038. ISSN 1465-7392. PMID 10854325. 
  5. ^ Huang, J; Gao X; Li S; Cao Z (November 1997). "Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (24): 12829–32. doi:10.1073/pnas.94.24.12829. ISSN 0027-8424. PMC 24223. PMID 9371760. 

Further reading[edit]