IL2RA

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Interleukin 2 receptor, alpha
Protein IL2RA PDB 1z92.png
PDB rendering based on 1z92.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols IL2RA ; CD25; IDDM10; IL2R; TCGFR
External IDs OMIM147730 MGI96549 HomoloGene360 ChEMBL: 1778 GeneCards: IL2RA Gene
RNA expression pattern
PBB GE IL2RA 211269 s at tn.png
PBB GE IL2RA 206341 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3559 16184
Ensembl ENSG00000134460 ENSMUSG00000026770
UniProt P01589 P01590
RefSeq (mRNA) NM_000417 NM_008367
RefSeq (protein) NP_000408 NP_032393
Location (UCSC) Chr 10:
6.05 – 6.1 Mb
Chr 2:
11.64 – 11.69 Mb
PubMed search [1] [2]

Interleukin-2 receptor alpha chain is a protein that in humans is encoded by the IL2RA gene.[1]

The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is currently unknown.[2]

Infection by the protozoan Trypanosoma cruzi causes Chagas disease, characterized by a reduction in the amount of IL2RA expressed on the surface of immune cells. This leads to chronic immune suppression, becoming increasingly severe over the course of many years and ultimately resulting in death if left untreated.


References[edit]

  1. ^ Leonard WJ, Donlon TA, Lebo RV, Greene WC (Aug 1985). "Localization of the gene encoding the human interleukin-2 receptor on chromosome 10". Science 228 (4707): 1547–9. doi:10.1126/science.3925551. PMID 3925551. 
  2. ^ "Entrez Gene: IL2RA interleukin 2 receptor, alpha". 

Further reading[edit]