IL31RA

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Interleukin 31 receptor A
Identifiers
Symbols IL31RA ; CRL; CRL3; GLM-R; GLMR; GPL; IL-31RA; PLCA2; PRO21384; hGLM-R
External IDs OMIM609510 MGI2180511 HomoloGene51395 GeneCards: IL31RA Gene
Orthologs
Species Human Mouse
Entrez 133396 218624
Ensembl ENSG00000164509 ENSMUSG00000050377
UniProt Q8NI17 Q8K5B1
RefSeq (mRNA) NM_001242636 NM_139299
RefSeq (protein) NP_001229565 NP_647460
Location (UCSC) Chr 5:
55.15 – 55.22 Mb
Chr 13:
112.52 – 112.58 Mb
PubMed search [1] [2]

Interleukin-31 receptor A is a protein that in humans is encoded by the IL31RA gene.[1][2][3]

IL31RA is related to gp130 (IL6ST; MIM 600694), the common receptor subunit for IL6 (MIM 147620)-type cytokines. Oncostatin M receptor (OSMR; MIM 601743) and IL31RA form the heterodimeric receptor through which IL31 (MIM 609509) signals. Expression of IL31RA and OSMR mRNA is induced in activated monocytes, and both mRNAs are constitutively expressed in epithelial cells (Dillon et al., 2004).[supplied by OMIM][3]

References[edit]

  1. ^ Dillon SR, Sprecher C, Hammond A, Bilsborough J, Rosenfeld-Franklin M, Presnell SR, Haugen HS, Maurer M, Harder B, Johnston J, Bort S, Mudri S, Kuijper JL, Bukowski T, Shea P, Dong DL, Dasovich M, Grant FJ, Lockwood L, Levin SD, LeCiel C, Waggie K, Day H, Topouzis S, Kramer J, Kuestner R, Chen Z, Foster D, Parrish-Novak J, Gross JA (Jun 2004). "Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice". Nat Immunol 5 (7): 752–60. doi:10.1038/ni1084. PMID 15184896. 
  2. ^ Ghilardi N, Li J, Hongo JA, Yi S, Gurney A, de Sauvage FJ (May 2002). "A novel type I cytokine receptor is expressed on monocytes, signals proliferation, and activates STAT-3 and STAT-5". J Biol Chem 277 (19): 16831–6. doi:10.1074/jbc.M201140200. PMID 11877449. 
  3. ^ a b "Entrez Gene: IL31RA interleukin 31 receptor A". 

Further reading[edit]