IL3RA

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Interleukin 3 receptor, alpha (low affinity)
Identifiers
Symbols IL3RA ; CD123; IL3R; IL3RAY; IL3RX; IL3RY; hIL-3Ra
External IDs OMIM430000 MGI96553 HomoloGene48088 GeneCards: IL3RA Gene
RNA expression pattern
PBB GE IL3RA 206148 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3563 16188
Ensembl ENSG00000185291 ENSMUSG00000068758
UniProt P26951 P26952
RefSeq (mRNA) NM_001267713 NM_008369
RefSeq (protein) NP_001254642 NP_032395
Location (UCSC) Chr X:
1.46 – 1.5 Mb
Chr 14:
14.35 – 14.36 Mb
PubMed search [1] [2]

Interleukin 3 receptor, alpha (low affinity) (IL3RA), also known as CD123 (Cluster of Differentiation 123), is a human gene.[1]

The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y.[1]

Interactions[edit]

IL3RA has been shown to interact with Interleukin 3.[2][3]

See also[edit]

References[edit]

  1. ^ a b "Entrez Gene: IL3RA interleukin 3 receptor, alpha (low affinity)". 
  2. ^ Stomski, F C; Sun Q; Bagley C J; Woodcock J; Goodall G; Andrews R K; Berndt M C; Lopez A F (June 1996). "Human interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity binding". Mol. Cell. Biol. (UNITED STATES) 16 (6): 3035–46. ISSN 0270-7306. PMC 231298. PMID 8649415. 
  3. ^ Woodcock, J M; Zacharakis B; Plaetinck G; Bagley C J; Qiyu S; Hercus T R; Tavernier J; Lopez A F (November 1994). "Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF". EMBO J. (ENGLAND) 13 (21): 5176–85. ISSN 0261-4189. PMC 395466. PMID 7957082. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.