ING1

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Inhibitor of growth family, member 1
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ING1 ; p24ING1c; p33; p33ING1; p33ING1b; p47; p47ING1a
External IDs OMIM601566 MGI1349481 HomoloGene40119 GeneCards: ING1 Gene
RNA expression pattern
PBB GE ING1 209808 x at tn.png
PBB GE ING1 208415 x at tn.png
PBB GE ING1 210350 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3621 26356
Ensembl ENSG00000153487 ENSMUSG00000045969
UniProt Q9UK53 Q9QXV3
RefSeq (mRNA) NM_001267728 NM_011919
RefSeq (protein) NP_001254657 NP_036049
Location (UCSC) Chr 13:
111.37 – 111.37 Mb
Chr 8:
11.56 – 11.56 Mb
PubMed search [1] [2]

Inhibitor of growth protein 1 is a protein that in humans is encoded by the ING1 gene.[1][2][3]

This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.[3]

Location on Chromosome 13[edit]

ING1 is located near the following genes on Chromosome 13

  • CARKD Carbohydrate Kinase Domain-Containing Protein (Unknown Function)
  • COL4A2: A2 Subunit of type IV collagen
  • RAB20: Potential regulator of Connexin 43 trafficking.
  • CARS2: Mitochondrial Cystienyl-tRNA Synthetase 2

Interactions[edit]

ING1 has been shown to interact with HDAC1,[4][5] DMAP1,[6] PCNA,[7] SIN3A,[5] SAP30,[5] P53,[8][9] SMARCC1,[5] CREB binding protein[4] and SMARCA4.[5]

References[edit]

  1. ^ Garkavtsev I, Kazarov A, Gudkov A, Riabowol K (Jan 1997). "Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation". Nat Genet 14 (4): 415–20. doi:10.1038/ng1296-415. PMID 8944021. 
  2. ^ Garkavtsev I, Demetrick D, Riabowol K (Jul 1997). "Cellular localization and chromosome mapping of a novel candidate tumor suppressor gene (ING1)". Cytogenet Cell Genet 76 (3-4): 176–8. doi:10.1159/000134539. PMID 9186514. 
  3. ^ a b "Entrez Gene: ING1 inhibitor of growth family, member 1". 
  4. ^ a b Vieyra, Diego; Loewith Robbie, Scott Michelle, Bonnefin Paul, Boisvert Francois-Michel, Cheema Parneet, Pastyryeva Svitlana, Meijer Maria, Johnston Randal N, Bazett-Jones David P, McMahon Steven, Cole Michael D, Young Dallan, Riabowol Karl (Aug 2002). "Human ING1 proteins differentially regulate histone acetylation". J. Biol. Chem. (United States) 277 (33): 29832–9. doi:10.1074/jbc.M200197200. ISSN 0021-9258. PMID 12015309. 
  5. ^ a b c d e Kuzmichev, A; Zhang Y; Erdjument-Bromage H; Tempst P; Reinberg D (Feb 2002). "Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)". Mol. Cell. Biol. (United States) 22 (3): 835–48. doi:10.1128/MCB.22.3.835-848.2002. ISSN 0270-7306. PMC 133546. PMID 11784859. 
  6. ^ Xin, Huawei; Yoon Ho-Guen; Singh Prim B; Wong Jiemin; Qin Jun (Mar 2004). "Components of a pathway maintaining histone modification and heterochromatin protein 1 binding at the pericentric heterochromatin in Mammalian cells". J. Biol. Chem. (United States) 279 (10): 9539–46. doi:10.1074/jbc.M311587200. ISSN 0021-9258. PMID 14665632. 
  7. ^ Scott, M; Bonnefin P; Vieyra D; Boisvert F M; Young D; Bazett-Jones D P; Riabowol K (Oct 2001). "UV-induced binding of ING1 to PCNA regulates the induction of apoptosis". J. Cell. Sci. (England) 114 (Pt 19): 3455–62. ISSN 0021-9533. PMID 11682605. 
  8. ^ Leung, Ka Man; Po Lai See; Tsang Fan Cheung; Siu Wai Yi; Lau Anita; Ho Horace T B; Poon Randy Y C (Sep 2002). "The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2". Cancer Res. (United States) 62 (17): 4890–3. ISSN 0008-5472. PMID 12208736. 
  9. ^ Garkavtsev, I; Grigorian I A; Ossovskaya V S; Chernov M V; Chumakov P M; Gudkov A V (Jan 1998). "The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control". Nature (ENGLAND) 391 (6664): 295–8. doi:10.1038/34675. ISSN 0028-0836. PMID 9440695. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.