ING5

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Inhibitor of growth family, member 5
Protein ING5 PDB 1wen.png
PDB rendering based on 1wen.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ING5 ; p28ING5
External IDs OMIM608525 HomoloGene90955 GeneCards: ING5 Gene
Orthologs
Species Human Mouse
Entrez 84289 66262
Ensembl ENSG00000168395 ENSMUSG00000026283
UniProt Q8WYH8 Q9D8Y8
RefSeq (mRNA) NM_032329 NM_025454
RefSeq (protein) NP_115705 NP_079730
Location (UCSC) Chr 2:
242.64 – 242.67 Mb
Chr 1:
93.8 – 93.82 Mb
PubMed search [1] [2]

Inhibitor of growth protein 5 is a protein that in humans is encoded by the ING5 gene.[1][2]

The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway.[2]

Interactions[edit]

ING5 has been shown to interact with EP300[1] and P53.[1]

References[edit]

  1. ^ a b c Shiseki M, Nagashima M, Pedeux RM, Kitahama-Shiseki M, Miura K, Okamura S, Onogi H, Higashimoto Y, Appella E, Yokota J, Harris CC (May 2003). "p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity". Cancer Res 63 (10): 2373–8. PMID 12750254. 
  2. ^ a b "Entrez Gene: ING5 inhibitor of growth family, member 5". 

Further reading[edit]