INHBC

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Inhibin, beta C
Identifiers
Symbols INHBC ; IHBC
External IDs OMIM601233 MGI105932 HomoloGene21142 GeneCards: INHBC Gene
RNA expression pattern
PBB GE INHBC 207687 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3626 16325
Ensembl ENSG00000175189 ENSMUSG00000025405
UniProt P55103 P55104
RefSeq (mRNA) NM_005538 NM_010565
RefSeq (protein) NP_005529 NP_034695
Location (UCSC) Chr 12:
57.83 – 57.84 Mb
Chr 10:
127.36 – 127.37 Mb
PubMed search [1] [2]

Inhibin beta C chain is a protein that in humans is encoded by the INHBC gene.[1][2]

This gene encodes the beta C chain of inhibin, a member of the TGF-beta superfamily. This subunit forms heterodimers with beta A and beta B subunits. Inhibins and activins, also members of the TGF-beta superfamily, are hormones with opposing actions and are involved in hypothalamic, pituitary, and gonadal hormone secretion, as well as growth and differentiation of various cell types.[2]

References[edit]

  1. ^ H tten G, Neidhardt H, Schneider C, Pohl J (Feb 1995). "Cloning of a new member of the TGF-beta family: a putative new activin beta C chain". Biochem Biophys Res Commun 206 (2): 608–13. doi:10.1006/bbrc.1995.1086. PMID 7826378. 
  2. ^ a b "Entrez Gene: INHBC inhibin, beta C". 

Further reading[edit]

  • Bernard DJ, Chapman SC, Woodruff TK (2001). "Mechanisms of inhibin signal transduction.". Recent Prog. Horm. Res. 56: 417–50. doi:10.1210/rp.56.1.417. PMID 11237224. 
  • Mathews LS, Vale WW (1991). "Expression cloning of an activin receptor, a predicted transmembrane serine kinase.". Cell 65 (6): 973–82. doi:10.1016/0092-8674(91)90549-E. PMID 1646080. 
  • Schmitt J, Hötten G, Jenkins NA, et al. (1997). "Structure, chromosomal localization, and expression analysis of the mouse inhibin/activin beta C (Inhbc) gene.". Genomics 32 (3): 358–66. doi:10.1006/geno.1996.0130. PMID 8838799. 
  • Thomas TZ, Chapman SM, Hong W, et al. (1998). "Inhibins, activins, and follistatins: expression of mRNAs and cellular localization in tissues from men with benign prostatic hyperplasia.". Prostate 34 (1): 34–43. doi:10.1002/(SICI)1097-0045(19980101)34:1<34::AID-PROS5>3.0.CO;2-K. PMID 9428386. 
  • Mellor SL, Cranfield M, Ries R, et al. (2001). "Localization of activin beta(A)-, beta(B)-, and beta(C)-subunits in humanprostate and evidence for formation of new activin heterodimers of beta(C)-subunit.". J. Clin. Endocrinol. Metab. 85 (12): 4851–8. doi:10.1210/jc.85.12.4851. PMID 11134153. 
  • Casagrandi D, Bearfield C, Geary J, et al. (2003). "Inhibin, activin, follistatin, activin receptors and beta-glycan gene expression in the placental tissue of patients with pre-eclampsia.". Mol. Hum. Reprod. 9 (4): 199–203. doi:10.1093/molehr/gag029. PMID 12651901. 
  • Mellor SL, Ball EM, O'Connor AE, et al. (2003). "Activin betaC-subunit heterodimers provide a new mechanism of regulating activin levels in the prostate.". Endocrinology 144 (10): 4410–9. doi:10.1210/en.2003-0225. PMID 12960042. 
  • Ushiro Y, Hashimoto O, Seki M, et al. (2007). "Analysis of the function of activin betaC subunit using recombinant protein.". J. Reprod. Dev. 52 (4): 487–95. doi:10.1262/jrd.17110. PMID 16627954.