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IQ motif containing GTPase activating protein 2
Available structures
PDB Ortholog search: PDBe, RCSB
Symbol IQGAP2
External IDs OMIM605401 HomoloGene101543 GeneCards: IQGAP2 Gene
RNA expression pattern
PBB GE IQGAP2 203474 at tn.png
More reference expression data
Species Human Mouse
Entrez 10788 544963
Ensembl ENSG00000145703 ENSMUSG00000021676
UniProt Q13576 Q3UQ44
RefSeq (mRNA) NM_001285460 NM_027711
RefSeq (protein) NP_001272389 NP_081987
Location (UCSC) Chr 5:
75.7 – 76 Mb
Chr 13:
95.63 – 95.89 Mb
PubMed search [1] [2]

Ras GTPase-activating-like protein IQGAP2 is an enzyme that in humans is encoded by the IQGAP2 gene.[1][2]


This gene encodes a member of the IQGAP family. The protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility.[2]


IQGAP2 has been shown to interact with CDC42[1] and RAC1.[1]


Further reading[edit]