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Interleukin-1 receptor-associated kinase 2
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols IRAK2 ; IRAK-2
External IDs OMIM603304 MGI2429603 HomoloGene1207 IUPHAR: 2043 GeneCards: IRAK2 Gene
RNA expression pattern
PBB GE IRAK2 gnf1h00036 at tn.png
More reference expression data
Species Human Mouse
Entrez 3656 108960
Ensembl ENSG00000134070 ENSMUSG00000060477
UniProt O43187 Q8CFA1
RefSeq (mRNA) NM_001570 NM_001113553
RefSeq (protein) NP_001561 NP_001107025
Location (UCSC) Chr 3:
10.21 – 10.29 Mb
Chr 6:
113.64 – 113.7 Mb
PubMed search [1] [2]

Interleukin-1 receptor-associated kinase-like 2 is an enzyme that in humans is encoded by the IRAK2 gene.[1][2]

IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB.[2]


IRAK2 has been shown to interact with TRAF6[1][3] and Myd88.[1][3][4]


  1. ^ a b c Muzio M, Ni J, Feng P, Dixit VM (Dec 1997). "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling". Science 278 (5343): 1612–5. doi:10.1126/science.278.5343.1612. PMID 9374458. 
  2. ^ a b "Entrez Gene: IRAK2 interleukin-1 receptor-associated kinase 2". 
  3. ^ a b Wesche, H; Gao X; Li X; Kirschning C J; Stark G R; Cao Z (Jul 1999). "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family". J. Biol. Chem. (UNITED STATES) 274 (27): 19403–10. doi:10.1074/jbc.274.27.19403. ISSN 0021-9258. PMID 10383454. 
  4. ^ Fitzgerald, K A; Palsson-McDermott E M, Bowie A G, Jefferies C A, Mansell A S, Brady G, Brint E, Dunne A, Gray P, Harte M T, McMurray D, Smith D E, Sims J E, Bird T A, O'Neill L A (Sep 2001). "Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction". Nature (England) 413 (6851): 78–83. doi:10.1038/35092578. ISSN 0028-0836. PMID 11544529. 

Further reading[edit]