IRAK2

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Interleukin-1 receptor-associated kinase 2
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols IRAK2 ; IRAK-2
External IDs OMIM603304 MGI2429603 HomoloGene1207 GeneCards: IRAK2 Gene
RNA expression pattern
PBB GE IRAK2 gnf1h00036 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3656 108960
Ensembl ENSG00000134070 ENSMUSG00000060477
UniProt O43187 Q8CFA1
RefSeq (mRNA) NM_001570 NM_001113553
RefSeq (protein) NP_001561 NP_001107025
Location (UCSC) Chr 3:
10.21 – 10.29 Mb
Chr 6:
113.64 – 113.7 Mb
PubMed search [1] [2]

Interleukin-1 receptor-associated kinase-like 2 is an enzyme that in humans is encoded by the IRAK2 gene.[1][2]

IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB.[2]

Interactions[edit]

IRAK2 has been shown to interact with TRAF6[1][3] and Myd88.[1][3][4]

References[edit]

  1. ^ a b c Muzio M, Ni J, Feng P, Dixit VM (Dec 1997). "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling". Science 278 (5343): 1612–5. doi:10.1126/science.278.5343.1612. PMID 9374458. 
  2. ^ a b "Entrez Gene: IRAK2 interleukin-1 receptor-associated kinase 2". 
  3. ^ a b Wesche, H; Gao X; Li X; Kirschning C J; Stark G R; Cao Z (Jul 1999). "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family". J. Biol. Chem. (UNITED STATES) 274 (27): 19403–10. doi:10.1074/jbc.274.27.19403. ISSN 0021-9258. PMID 10383454. 
  4. ^ Fitzgerald, K A; Palsson-McDermott E M, Bowie A G, Jefferies C A, Mansell A S, Brady G, Brint E, Dunne A, Gray P, Harte M T, McMurray D, Smith D E, Sims J E, Bird T A, O'Neill L A (Sep 2001). "Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction". Nature (England) 413 (6851): 78–83. doi:10.1038/35092578. ISSN 0028-0836. PMID 11544529. 

Further reading[edit]