IRF2

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Interferon regulatory factor 2
Protein IRF2 PDB 1irf.png
PDB rendering based on 1irf.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols IRF2 ; IRF-2
External IDs OMIM147576 MGI96591 HomoloGene1659 GeneCards: IRF2 Gene
RNA expression pattern
PBB GE IRF2 203275 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3660 16363
Ensembl ENSG00000168310 ENSMUSG00000031627
UniProt P14316 P23906
RefSeq (mRNA) NM_002199 NM_008391
RefSeq (protein) NP_002190 NP_032417
Location (UCSC) Chr 4:
185.31 – 185.4 Mb
Chr 8:
46.74 – 46.85 Mb
PubMed search [1] [2]

Interferon regulatory factor 2 is a protein that in humans is encoded by the IRF2 gene.[1]

IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4.[2]

See also[edit]

Interactions[edit]

IRF2 has been shown to interact with BRD7,[3] EP300[4] and PCAF.[4][5]

References[edit]

  1. ^ Harada H, Fujita T, Miyamoto M, Kimura Y, Maruyama M, Furia A, Miyata T, Taniguchi T (September 1989). "Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes". Cell 58 (4): 729–39. doi:10.1016/0092-8674(89)90107-4. PMID 2475256. 
  2. ^ "Entrez Gene: IRF2 interferon regulatory factor 2". 
  3. ^ Staal, A; Enserink J M; Stein J L; Stein G S; van Wijnen A J (November 2000). "Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2". J. Cell. Physiol. (UNITED STATES) 185 (2): 269–79. doi:10.1002/1097-4652(200011)185:2<269::AID-JCP12>3.0.CO;2-L. ISSN 0021-9541. PMID 11025449. 
  4. ^ a b Masumi, A; Ozato K (June 2001). "Coactivator p300 acetylates the interferon regulatory factor-2 in U937 cells following phorbol ester treatment". J. Biol. Chem. (United States) 276 (24): 20973–80. doi:10.1074/jbc.M101707200. ISSN 0021-9258. PMID 11304541. 
  5. ^ Masumi, A; Wang I M; Lefebvre B; Yang X J; Nakatani Y; Ozato K (March 1999). "The Histone Acetylase PCAF Is a Phorbol-Ester-Inducible Coactivator of the IRF Family That Confers Enhanced Interferon Responsiveness". Mol. Cell. Biol. (UNITED STATES) 19 (3): 1810–20. ISSN 0270-7306. PMC 83974. PMID 10022868. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.