ITGA10

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Integrin, alpha 10
Identifiers
Symbols ITGA10 ; PRO827
External IDs OMIM604042 MGI2153482 HomoloGene2697 ChEMBL: 5882 GeneCards: ITGA10 Gene
Orthologs
Species Human Mouse
Entrez 8515 213119
Ensembl ENSG00000143127 ENSMUSG00000090210
UniProt O75578 E9PXZ3
RefSeq (mRNA) NM_003637 NM_001081053
RefSeq (protein) NP_003628 NP_001074522
Location (UCSC) Chr 1:
145.52 – 145.54 Mb
Chr 3:
96.65 – 96.66 Mb
PubMed search [1] [2]

Integrin alpha-10 also known as ITGA10 is a protein that in humans is encoded by the ITGA10 gene.[1][2][3]

Function[edit]

Integrins are integral membrane proteins composed of an alpha chain and a beta chain, and are known to participate in cell adhesion as well as cell-surface mediated signalling. The I-domain containing alpha 10 combines with the integrin beta 1 chain (ITGB1) to form a novel collagen type II-binding integrin expressed in cartilage tissue.[1]

Related gene problems[edit]

References[edit]

  1. ^ a b "Entrez Gene: ITGA10 integrin, alpha 10". 
  2. ^ Camper L, Hellman U, Lundgren-Akerlund E (August 1998). "Isolation, cloning, and sequence analysis of the integrin subunit alpha10, a beta1-associated collagen binding integrin expressed on chondrocytes". J. Biol. Chem. 273 (32): 20383–9. doi:10.1074/jbc.273.32.20383. PMID 9685391. 
  3. ^ Lehnert K, Ni J, Leung E, Gough S, Morris CM, Liu D, Wang SX, Langley R, Krissansen GW (1999). "The integrin alpha10 subunit: expression pattern, partial gene structure, and chromosomal localization". Cytogenet. Cell Genet. 87 (3–4): 238–44. doi:10.1159/000015434. PMID 10702680. 
  4. ^ Klopocki E, Schulze H, Strauss G, et al. (February 2007). "Complex Inheritance Pattern Resembling Autosomal Recessive Inheritance Involving a Microdeletion in Thrombocytopenia–Absent Radius Syndrome". Am. J. Hum. Genet. 80 (2): 232–40. doi:10.1086/510919. PMC 1785342. PMID 17236129. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.