ITGA11

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Integrin, alpha 11
Identifiers
Symbols ITGA11 ; HsT18964
External IDs OMIM604789 MGI2442114 HomoloGene8151 ChEMBL: 5883 GeneCards: ITGA11 Gene
RNA expression pattern
PBB GE ITGA11 gnf1h00121 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 22801 319480
Ensembl ENSG00000137809 ENSMUSG00000032243
UniProt Q9UKX5 Q7TQC3
RefSeq (mRNA) NM_001004439 NM_176922
RefSeq (protein) NP_001004439 NP_795896
Location (UCSC) Chr 15:
68.59 – 68.72 Mb
Chr 9:
62.68 – 62.78 Mb
PubMed search [1] [2]

Integrin alpha-11 is a protein that in humans is encoded by the ITGA11 gene.[1][2]

This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined.[2]

According to one study, ITGA11 expression is increased in the anterior stroma of corneal buttons excised from the eyes affected by keratoconus.[3]

References[edit]

  1. ^ Lehnert K, Ni J, Leung E, Gough SM, Weaver A, Yao WP, Liu D, Wang SX, Morris CM, Krissansen GW (Nov 1999). "Cloning, sequence analysis, and chromosomal localization of the novel human integrin alpha11 subunit (ITGA11)". Genomics 60 (2): 179–87. doi:10.1006/geno.1999.5909. PMID 10486209. 
  2. ^ a b "Entrez Gene: ITGA11 integrin, alpha 11". 
  3. ^ Byström B, Carracedo S, Behndig AB, Gullberg D, Pedrosa-Domellof F (June 2009). "{alpha}11 integrin in the human cornea-importance in development and disease". Invest. Ophthalmol. Vis. Sci. 50 (11): 5044–53. doi:10.1167/iovs.08-3261. PMID 19516006. 

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