ITGA2B

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
Protein ITGA2B PDB 1txv.png
PDB rendering based on 1txv.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ITGA2B ; BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb; GT; GTA; HPA3; PPP1R93
External IDs OMIM607759 MGI96601 HomoloGene37304 ChEMBL: 212 GeneCards: ITGA2B Gene
RNA expression pattern
PBB GE ITGA2B 206493 at tn.png
PBB GE ITGA2B 206494 s at tn.png
PBB GE ITGA2B 216956 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3674 16399
Ensembl ENSG00000005961 ENSMUSG00000034664
UniProt P08514 Q9QUM0
RefSeq (mRNA) NM_000419 NM_010575
RefSeq (protein) NP_000410 NP_034705
Location (UCSC) Chr 17:
42.45 – 42.47 Mb
Chr 11:
102.45 – 102.47 Mb
PubMed search [1] [2]

Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene.

ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibrinogen receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.[1]

Interactions[edit]

ITGA2B has been shown to interact with AUP1[2] and CLNS1A.[3]

See also[edit]

References[edit]

  1. ^ "Entrez Gene: ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)". 
  2. ^ Kato, Atsushi; Kawamata Norihiko; Tamayose Kenji; Egashira Motoki; Miura Rika; Fujimura Tsutomu; Murayama Kimie; Oshimi Kazuo (Aug 2002). "Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3". J. Biol. Chem. (United States) 277 (32): 28934–41. doi:10.1074/jbc.M204340200. ISSN 0021-9258. PMID 12042322. 
  3. ^ Larkin, Deirdre; Murphy Derek; Reilly Dermot F; Cahill Martha; Sattler Ellen; Harriott Pat; Cahill Dolores J; Moran Niamh (Jun 2004). "ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation". J. Biol. Chem. (United States) 279 (26): 27286–93. doi:10.1074/jbc.M402159200. ISSN 0021-9258. PMID 15075326. 

Further reading[edit]

External links[edit]