ITGA5

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Integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ITGA5 ; CD49e; FNRA; VLA5A
External IDs OMIM135620 MGI96604 HomoloGene20508 ChEMBL: 3955 GeneCards: ITGA5 Gene
RNA expression pattern
PBB GE ITGA5 201389 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3678 16402
Ensembl ENSG00000161638 ENSMUSG00000000555
UniProt P08648 P11688
RefSeq (mRNA) NM_002205 NM_010577
RefSeq (protein) NP_002196 NP_034707
Location (UCSC) Chr 12:
54.79 – 54.81 Mb
Chr 15:
103.34 – 103.37 Mb
PubMed search [1] [2]

Integrin alpha-5 is a protein that in humans is encoded by the ITGA5 gene.[1]

The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.[2]

Interactions[edit]

ITGA5 has been shown to interact with GIPC1.[3]

See also[edit]

References[edit]

  1. ^ Sosnoski DM, Emanuel BS, Hawkins AL, van Tuinen P, Ledbetter DH, Nussbaum RL, Kaos FT, Schwartz E, Phillips D, Bennett JS, et al. (Aug 1988). "Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa". J Clin Invest 81 (6): 1993–8. doi:10.1172/JCI113548. PMC 442653. PMID 2454952. 
  2. ^ "Entrez Gene: ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)". 
  3. ^ Tani, T T; Mercurio A M (Sep 2001). "PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B". J. Biol. Chem. (United States) 276 (39): 36535–42. doi:10.1074/jbc.M105785200. ISSN 0021-9258. PMID 11479315. 

Further reading[edit]

  • Ruoslahti E (1996). "Integrin signaling and matrix assembly.". Tumour Biol. 17 (2): 117–24. doi:10.1159/000217975. PMID 8658014. 
  • Coulombel L, Auffray I, Gaugler MH, Rosemblatt M (1997). "Expression and function of integrins on hematopoietic progenitor cells.". Acta Haematol. 97 (1–2): 13–21. doi:10.1159/000203655. PMID 8980606. 
  • Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors". Trends Cell Biol. 8 (10): 390–6. doi:10.1016/S0962-8924(98)01344-0. PMID 9789327. 
  • Evans JP (2001). "Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization". Bioessays 23 (7): 628–39. doi:10.1002/bies.1088. PMID 11462216. 

External links[edit]