ITGA6

Integrin, alpha 6
Identifiers
Symbols	ITGA6; CD49f; ITGA6B; VLA-6
External IDs	OMIM: 147556 MGI: 96605 HomoloGene: 20091 GeneCards: ITGA6 Gene
Gene Ontology
Molecular function	• receptor activity; • protein binding;
Cellular component	• plasma membrane; • plasma membrane; • integrin complex; • integral to membrane;
Biological process	• cell-substrate junction assembly; • cell adhesion; • integrin-mediated signaling pathway; • blood coagulation; • hemidesmosome assembly; • cell junction assembly; • positive regulation of phosphorylation; • positive regulation of apoptotic process; • negative regulation of apoptotic process; • positive regulation of transcription from RNA polymerase II promoter; • leukocyte migration;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	This box: view; talk; edit;

From Wikipedia, the free encyclopedia

Jump to: navigation, search

Integrin alpha-6 is a protein that in humans is encoded by the ITGA6 gene.

The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.^[1]

[edit] Interactions

ITGA6 has been shown to interact with TSPAN4^[2] and GIPC1.^[3]

[edit] See also

[edit] References

^ "Entrez Gene: ITGA6 integrin, alpha 6". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3655.
^ Tachibana, I; Bodorova J, Berditchevski F, Zutter M M, Hemler M E (November 1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". J. Biol. Chem. (UNITED STATES) 272 (46): 29181–9. doi:10.1074/jbc.272.46.29181. ISSN 0021-9258. PMID 9360996.
^ Tani, T T; Mercurio A M (September 2001). "PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B". J. Biol. Chem. (United States) 276 (39): 36535–42. doi:10.1074/jbc.M105785200. ISSN 0021-9258. PMID 11479315.

[edit] Further reading

Lipscomb EA, Mercurio AM (2006). "Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression.". Cancer Metastasis Rev. 24 (3): 413–23. doi:10.1007/s10555-005-5133-4. PMID 16258729.

[edit] External links

MeSH CD49f+Antigen
ITGA6 Info with links in the Cell Migration Gateway

This membrane protein-related article is a stub. You can help Wikipedia by expanding it.

[0] "Entrez Gene: ITGA6 integrin, alpha 6". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3655.

[pmid9360996-1] Tachibana, I; Bodorova J, Berditchevski F, Zutter M M, Hemler M E (November 1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". J. Biol. Chem. (UNITED STATES) 272 (46): 29181–9. doi:10.1074/jbc.272.46.29181. ISSN 0021-9258. PMID 9360996.

[pmid11479315-2] Tani, T T; Mercurio A M (September 2001). "PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B". J. Biol. Chem. (United States) 276 (39): 36535–42. doi:10.1074/jbc.M105785200. ISSN 0021-9258. PMID 11479315.

[1]

[2]

[3]

ITGA6

Contents

[edit] Interactions

[edit] See also

[edit] References

[edit] Further reading

[edit] External links

Personal tools

Namespaces

Variants

Views

Actions

Search

Navigation

Interaction

Toolbox

Print/export

Languages