From Wikipedia, the free encyclopedia
Jump to: navigation, search
Integrin, alpha 7
Symbols ITGA7 ; FLJ25220
External IDs OMIM600536 MGI102700 HomoloGene37592 IUPHAR: 2446 GeneCards: ITGA7 Gene
RNA expression pattern
PBB GE ITGA7 216331 at tn.png
PBB GE ITGA7 209663 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3679 16404
Ensembl ENSG00000135424 ENSMUSG00000025348
UniProt Q13683 Q61738
RefSeq (mRNA) NM_001144996 NM_008398
RefSeq (protein) NP_001138468 NP_032424
Location (UCSC) Chr 12:
56.08 – 56.11 Mb
Chr 10:
128.93 – 128.96 Mb
PubMed search [1] [2]

Integrin alpha-7 is a protein that in humans is encoded by the ITGA7 gene.[1][2]


ITGA7 encodes integrin alpha chain 7. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 7 undergoes post-translational cleavage within the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that binds to the extracellular matrix protein laminin-1. Alpha 7 beta 1 is the major integrin complex expressed in differentiated muscle cells. Splice variants of alpha 7 that differ in both the extracellular and cytoplasmic domains exist in the mouse; however, to date only a single human transcript type has been isolated: it contains extracellular and cytoplasmic domains corresponding to the mouse X2 and B variants, respectively. A unique extracellular splice variant has been identified in human, although it clearly represents a minor species and its biological significance is unclear.[2]


ITGA7 has been shown to interact with FHL2[3] and FHL3.[3]

See also[edit]


  1. ^ Wang W, Wu W, Desai T, Ward DC, Kaufman SJ (Aug 1995). "Localization of the alpha 7 integrin gene (ITGA7) on human chromosome 12q13: clustering of integrin and Hox genes implies parallel evolution of these gene families". Genomics 26 (3): 568–70. doi:10.1016/0888-7543(95)80176-M. PMID 7607681. 
  2. ^ a b "Entrez Gene: ITGA7 integrin, alpha 7". 
  3. ^ a b Samson T, Smyth N, Janetzky S, Wendler O, Müller JM, Schüle R et al. (Jul 2004). "The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor". J. Biol. Chem. 279 (27): 28641–52. doi:10.1074/jbc.M312894200. PMID 15117962. 

Further reading[edit]

External links[edit]