ITGAE

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Integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
Identifiers
Symbols ITGAE ; CD103; HUMINAE
External IDs OMIM604682 MGI1298377 HomoloGene113560 GeneCards: ITGAE Gene
Orthologs
Species Human Mouse
Entrez 3682 16407
Ensembl ENSG00000083457 ENSMUSG00000005947
UniProt P38570 Q60677
RefSeq (mRNA) NM_002208 NM_008399
RefSeq (protein) NP_002199 NP_032425
Location (UCSC) Chr 17:
3.62 – 3.7 Mb
Chr 11:
73.09 – 73.15 Mb
PubMed search [1] [2]

Integrin, alpha E (ITGAE) also known as CD103 (cluster of differentiation 103) is an integrin protein that in human is encoded by the ITGAE gene.[1][2] CD103 binds integrin beta 7 (β7– ITGB7) to form the complete heterodimeric integrin molecule αEβ7, which has no distinct name. The αEβ7 complex is often referred to as "CD103" though this appellation strictly refers only to the αE chain. Note that the β7 subunit can bind with other integrin α chains, such as α4 (CD49d).

Tissue distribution[edit]

CD103 is expressed widely on intraepithelial lymphocyte (IEL) T cells (both αβ T cells and γδ T cells) and on some peripheral regulatory T cells (Tregs).[3] It has also been reported on lamina propria T cells.[4] A subset of dendritic cells in the gut mucosa and in mesenteric lymph nodes also expresses this marker and is known as CD103 DCs.[5]

It is useful in identifying Hairy cell leukemia which is positive for this marker in contrast to most other hematologic malignancies which are negative for CD103 except Enteropathy associated T cell lymphoma.[6]

Function[edit]

The chief ligand for αEβ7 is E-cadherin, an adhesion molecule (CAM) found on epithelial cells.[7] It is probably important for T cell homing to the intestinal sites.[8]

Tregs are important for decreasing the immune response and appear to play a crucial role in the prevention of autoimmune diseases. Tregs are defined as CD4+/CD25+/Foxp3+ cells.[9] Some CD4+/FoxP3- cells also express CD103 and have been attributed regulatory activity. It is unclear whether the presence of CD103 on Treg cells represents a specialized feature for Treg, or Treg differentiation of IEL T cells.

See also[edit]

References[edit]

  1. ^ Kilshaw PJ, Higgins JM (2002). "Alpha E: no more rejection?". J. Exp. Med. 196 (7): 873–5. doi:10.1084/jem.20021404. PMC 2194032. PMID 12370249. 
  2. ^ "Entrez Gene: integrin". 
  3. ^ Lehmann J, Huehn J, de la Rosa M, Maszyna F, Kretschmer U, Krenn V, Brunner M, Scheffold A, Hamann A (October 2002). "Expression of the integrin alpha Ebeta 7 identifies unique subsets of CD25+ as well as CD25- regulatory T cells". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 13031–6. doi:10.1073/pnas.192162899. PMC 130581. PMID 12242333. 
  4. ^ Aziz S, Fackler OT, Meyerhans A, Müller-Lantzsch N, Zeitz M, Schneider T (January 2005). "Replication of M-tropic HIV-1 in activated human intestinal lamina propria lymphocytes is the main reason for increased virus load in the intestinal mucosa". J. Acquir. Immune Defic. Syndr. 38 (1): 23–30. doi:10.1097/00126334-200501010-00005. PMID 15608520. 
  5. ^ Johansson-Lindbom B, Svensson M, Pabst O, Palmqvist C, Marquez G, Förster R, Agace WW (October 2005). "Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing". J. Exp. Med. 202 (8): 1063–73. doi:10.1084/jem.20051100. PMC 2213212. PMID 16216890. 
  6. ^ Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (2008). WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (World Health Organization Classification of Tumours) (4 ed.). Geneva: World Health Organization. ISBN 92-832-2431-0. 
  7. ^ Hadley GA, Bartlett ST, Via CS, Rostapshova EA, Moainie S (October 1997). "The epithelial cell-specific integrin, CD103 (alpha E integrin), defines a novel subset of alloreactive CD8+ CTL". J. Immunol. 159 (8): 3748–56. PMID 9378961. 
  8. ^ Agace WW, Higgins JM, Sadasivan B, Brenner MB, Parker CM (October 2000). "T-lymphocyte-epithelial-cell interactions: integrin alpha(E)(CD103)beta(7), LEEP-CAM and chemokines". Curr. Opin. Cell Biol. 12 (5): 563–8. doi:10.1016/S0955-0674(00)00132-0. PMID 10978890. 
  9. ^ Allakhverdi Z, Fitzpatrick D, Boisvert A, Baba N, Bouguermouh S, Sarfati M, Delespesse G (December 2006). "Expression of CD103 identifies human regulatory T-cell subsets". J. Allergy Clin. Immunol. 118 (6): 1342–9. doi:10.1016/j.jaci.2006.07.034. PMID 17137867. 

Further reading[edit]

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