ITGAV

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Integrin, alpha V
PDB 1jv2 EBI.jpg
Rendering of 1JV2
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ITGAV ; CD51; MSK8; VNRA; VTNR
External IDs OMIM193210 MGI96608 HomoloGene20510 ChEMBL: 3660 GeneCards: ITGAV Gene
RNA expression pattern
PBB GE ITGAV 202351 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3685 16410
Ensembl ENSG00000138448 ENSMUSG00000027087
UniProt P06756 P43406
RefSeq (mRNA) NM_001144999 NM_008402
RefSeq (protein) NP_001138471 NP_032428
Location (UCSC) Chr 2:
187.45 – 187.55 Mb
Chr 2:
83.72 – 83.81 Mb
PubMed search [1] [2]

Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene.[1]

ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction.[2]

See also[edit]

References[edit]

  1. ^ Sosnoski DM, Emanuel BS, Hawkins AL, van Tuinen P, Ledbetter DH, Nussbaum RL, Kaos FT, Schwartz E, Phillips D, Bennett JS, et al. (Aug 1988). "Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa". J Clin Invest 81 (6): 1993–8. doi:10.1172/JCI113548. PMC 442653. PMID 2454952. 
  2. ^ "Entrez Gene: ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)". 

Further reading[edit]

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