ITGAV

Integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
Rendering of 1JV2
Available structures PDB 1JV2, 1L5G, 1M1X, 1U8C, 3IJE
Identifiers
Symbols	ITGAV; CD51; DKFZp686A08142; MSK8; VNRA
External IDs	OMIM: 193210 MGI: 96608 HomoloGene: 20510 GeneCards: ITGAV Gene
Gene Ontology Molecular function • opsonin binding • receptor activity • protein binding • insulin-like growth factor I binding • transforming growth factor beta binding • protein kinase C alpha binding Cellular component • plasma membrane • plasma membrane • plasma membrane • integral to plasma membrane • integrin complex • integrin complex • external side of plasma membrane • cell surface • cell surface • membrane Biological process • angiogenesis • blood vessel development • cell adhesion • cell-matrix adhesion • integrin-mediated signaling pathway • axon guidance • blood coagulation • positive regulation of cell proliferation • negative regulation of macrophage derived foam cell differentiation • negative regulation of lipid storage • negative regulation of lipid transport • entry of bacterium into host cell • negative regulation of apoptosis • interspecies interaction between organisms • negative regulation of low-density lipoprotein particle receptor biosynthetic process • positive regulation of cell adhesion • entry of virus into host cell • negative regulation of lipoprotein metabolic process • regulation of phagocytosis • leukocyte migration • entry of symbiont into host cell by promotion of host phagocytosis • ERK1 and ERK2 cascade • regulation of apoptotic cell clearance Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3685	16410
Ensembl	ENSG00000138448	ENSMUSG00000027087
UniProt	P06756	Q3U4C8
RefSeq (mRNA)	NM_001144999.1	NM_008402.2
RefSeq (protein)	NP_001138471.1	NP_032428.2
Location (UCSC)	Chr 2: 187.45 – 187.55 Mb	Chr 2: 83.56 – 83.65 Mb
PubMed search	[1]	[2]

Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene.

ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction.

See also

• Cluster of differentiation

Further reading

• Horton MA (1997). "The alpha v beta 3 integrin "vitronectin receptor".". Int. J. Biochem. Cell Biol. 29 (5): 721–5. doi:10.1016/S1357-2725(96)00155-0. PMID 9251239. 
• Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors.". Trends Cell Biol. 8 (10): 390–6. doi:10.1016/S0962-8924(98)01344-0. PMID 9789327. 
• Sajid M, Stouffer GA (2002). "The role of alpha(v)beta3 integrins in vascular healing.". Thromb. Haemost. 87 (2): 187–93. PMID 11858476. 
• Cooper CR, Chay CH, Pienta KJ (2002). "The role of alpha(v)beta(3) in prostate cancer progression.". Neoplasia 4 (3): 191–4. doi:10.1038/sj/neo/7900224. PMC 1531692. PMID 11988838. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1531692. 
• Cacciari B, Spalluto G (2005). "Non peptidic alphavbeta3 antagonists: recent developments.". Curr. Med. Chem. 12 (1): 51–70. PMID 15638730. 

External links

• MeSH CD51+Antigen
• ITGAV Info with links in the Cell Migration Gateway