ITGB1BP1

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Integrin beta 1 binding protein 1
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ITGB1BP1 ; ICAP-1A; ICAP-1B; ICAP-1alpha; ICAP1; ICAP1A; ICAP1B
External IDs OMIM607153 MGI1306802 HomoloGene3496 GeneCards: ITGB1BP1 Gene
RNA expression pattern
PBB GE ITGB1BP1 203337 x at tn.png
PBB GE ITGB1BP1 203336 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9270 16413
Ensembl ENSG00000119185 ENSMUSG00000062352
UniProt O14713 O35671
RefSeq (mRNA) NM_004763 NM_008403
RefSeq (protein) NP_004754 NP_032429
Location (UCSC) Chr 2:
9.54 – 9.56 Mb
Chr 12:
21.24 – 21.29 Mb
PubMed search [1] [2]

Integrin beta-1-binding protein 1 is a protein that in humans is encoded by the ITGB1BP1 gene.[1][2][3]

The cytoplasmic domains of integrins are essential for cell adhesion. The protein encoded by this gene binds to the beta1 integrin cytoplasmic domain. The interaction between this protein and beta1 integrin is highly specific. Two isoforms of this protein are derived from alternatively spliced transcripts. The shorter form of this protein does not interact with the beta1 integrin cytoplasmic domain. The longer form is a phosphoprotein and the extent of its phosphorylation is regulated by the cell-matrix interaction, suggesting an important role of this protein during integrin-dependent cell adhesion.[3]

Interactions[edit]

ITGB1BP1 has been shown to interact with KRIT1,[1][4] LRP2,[5] CD29[2][6] and LRP1.[5]

References[edit]

  1. ^ a b Zawistowski JS, Serebriiskii IG, Lee MF, Golemis EA, Marchuk DA (March 2002). "KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesis". Hum Mol Genet 11 (4): 389–96. doi:10.1093/hmg/11.4.389. PMID 11854171. 
  2. ^ a b Chang DD, Wong C, Smith H, Liu J (October 1997). "ICAP-1, a novel beta1 integrin cytoplasmic domain-associated protein, binds to a conserved and functionally important NPXY sequence motif of beta1 integrin". J Cell Biol 138 (5): 1149–57. doi:10.1083/jcb.138.5.1149. PMC 2136751. PMID 9281591. 
  3. ^ a b "Entrez Gene: ITGB1BP1 integrin beta 1 binding protein 1". 
  4. ^ Zhang, J; Clatterbuck R E; Rigamonti D; Chang D D; Dietz H C (December 2001). "Interaction between krit1 and icap1alpha infers perturbation of integrin beta1-mediated angiogenesis in the pathogenesis of cerebral cavernous malformation". Hum. Mol. Genet. (England) 10 (25): 2953–60. doi:10.1093/hmg/10.25.2953. ISSN 0964-6906. PMID 11741838. 
  5. ^ a b Gotthardt, M; Trommsdorff M; Nevitt M F; Shelton J; Richardson J A; Stockinger W; Nimpf J; Herz J (August 2000). "Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction". J. Biol. Chem. (UNITED STATES) 275 (33): 25616–24. doi:10.1074/jbc.M000955200. ISSN 0021-9258. PMID 10827173. 
  6. ^ Chang, David D; Hoang Bao Q; Liu Jenny; Springer Timothy A (March 2002). "Molecular basis for interaction between Icap1 alpha PTB domain and beta 1 integrin". J. Biol. Chem. (United States) 277 (10): 8140–5. doi:10.1074/jbc.M109031200. ISSN 0021-9258. PMID 11741908. 

Further reading[edit]