CD18

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Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
Protein ITGB2 PDB 1l3y.png
PDB rendering based on 1l3y.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ITGB2 ; CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7
External IDs OMIM600065 MGI96611 HomoloGene20092 ChEMBL: 3631 GeneCards: ITGB2 Gene
RNA expression pattern
PBB GE ITGB2 202803 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3689 16414
Ensembl ENSG00000160255 ENSMUSG00000000290
UniProt P05107 P11835
RefSeq (mRNA) NM_000211 NM_008404
RefSeq (protein) NP_000202 NP_032430
Location (UCSC) Chr 21:
46.31 – 46.35 Mb
Chr 10:
77.53 – 77.57 Mb
PubMed search [1] [2]

Integrin beta-2 (CD18) is a protein that in humans is encoded by the ITGB2 gene.

It is the beta subunit of four different structures:

The ITGB2 protein product is the integrin beta chain beta 2. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.[1] In humans lack of CD18 causes Leukocyte Adhesion Deficiency, a disease defined by a lack of leukocyte extravasation from blood into tissues.

Interactions[edit]

CD18 has been shown to interact with ICAM-1,[2][3][4] FHL2,[5] PSCD1[6][7] and GNB2L1.[8]

See also[edit]

References[edit]

  1. ^ "Entrez Gene: ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)". 
  2. ^ Kotovuori, A; Pessa-Morikawa T; Kotovuori P; Nortamo P; Gahmberg C G (June 1999). "ICAM-2 and a peptide from its binding domain are efficient activators of leukocyte adhesion and integrin affinity". J. Immunol. (UNITED STATES) 162 (11): 6613–20. ISSN 0022-1767. PMID 10352278. 
  3. ^ Lu, C; Takagi J; Springer T A (May 2001). "Association of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive state". J. Biol. Chem. (United States) 276 (18): 14642–8. doi:10.1074/jbc.M100600200. ISSN 0021-9258. PMID 11279101. 
  4. ^ Huang, C; Springer T A (August 1995). "A binding interface on the I domain of lymphocyte function-associated antigen-1 (LFA-1) required for specific interaction with intercellular adhesion molecule 1 (ICAM-1)". J. Biol. Chem. (UNITED STATES) 270 (32): 19008–16. doi:10.1074/jbc.270.32.19008. ISSN 0021-9258. PMID 7642561. 
  5. ^ Wixler, V; Geerts D; Laplantine E; Westhoff D; Smyth N; Aumailley M; Sonnenberg A; Paulsson M (October 2000). "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes". J. Biol. Chem. (UNITED STATES) 275 (43): 33669–78. doi:10.1074/jbc.M002519200. ISSN 0021-9258. PMID 10906324. 
  6. ^ Rietzler, M; Bittner M; Kolanus W; Schuster A; Holzmann B (October 1998). "The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins". J. Biol. Chem. (UNITED STATES) 273 (42): 27459–66. doi:10.1074/jbc.273.42.27459. ISSN 0021-9258. PMID 9765275. 
  7. ^ Geiger, C; Nagel W, Boehm T, van Kooyk Y, Figdor C G, Kremmer E, Hogg N, Zeitlmann L, Dierks H, Weber K S, Kolanus W (June 2000). "Cytohesin-1 regulates beta-2 integrin-mediated adhesion through both ARF-GEF function and interaction with LFA-1". EMBO J. (ENGLAND) 19 (11): 2525–36. doi:10.1093/emboj/19.11.2525. ISSN 0261-4189. PMC 212768. PMID 10835351. 
  8. ^ Liliental, J; Chang D D (January 1998). "Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit". J. Biol. Chem. (UNITED STATES) 273 (4): 2379–83. doi:10.1074/jbc.273.4.2379. ISSN 0021-9258. PMID 9442085. 

Further reading[edit]

  • Bunting M, Harris ES, McIntyre TM, et al. (2002). "Leukocyte adhesion deficiency syndromes: adhesion and tethering defects involving beta 2 integrins and selectin ligands.". Curr. Opin. Hematol. 9 (1): 30–5. doi:10.1097/00062752-200201000-00006. PMID 11753075. 
  • Roos D, Law SK (2003). "Hematologically important mutations: leukocyte adhesion deficiency.". Blood Cells Mol. Dis. 27 (6): 1000–4. doi:10.1006/bcmd.2001.0473. PMID 11831866. 
  • Gahmberg CG, Fagerholm S (2003). "Activation of leukocyte beta2-integrins.". Vox Sang. 83 Suppl 1: 355–8. doi:10.1111/j.1423-0410.2002.tb05333.x. PMID 12617168. 
  • Schymeinsky J, Mócsai A, Walzog B (2007). "Neutrophil activation via beta2 integrins (CD11/CD18): molecular mechanisms and clinical implications.". Thromb. Haemost. 98 (2): 262–73. doi:10.1160/th07-02-0156. PMID 17721605. 

External links[edit]