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Integrin beta 3 binding protein (beta3-endonexin)
Symbols ITGB3BP ; CENP-R; CENPR; HSU37139; NRIF3; TAP20
External IDs OMIM605494 MGI1914983 HomoloGene8617 GeneCards: ITGB3BP Gene
RNA expression pattern
PBB GE ITGB3BP 205176 s at tn.png
More reference expression data
Species Human Mouse
Entrez 23421 67733
Ensembl ENSG00000142856 ENSMUSG00000028549
UniProt Q13352 Q9CQ82
RefSeq (mRNA) NM_001206739 NM_026348
RefSeq (protein) NP_001193668 NP_080624
Location (UCSC) Chr 1:
63.91 – 64.06 Mb
Chr 4:
99.77 – 99.93 Mb
PubMed search [1] [2]

Centromere protein R is a protein that in humans is encoded by the ITGB3BP gene.[1][2][3]


ITGB3BP has been shown to interact with:


  1. ^ a b Shattil SJ, O'Toole T, Eigenthaler M, Thon V, Williams M, Babior BM, Ginsberg MH (December 1995). "Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit". J Cell Biol 131 (3): 807–16. doi:10.1083/jcb.131.3.807. PMC 2120613. PMID 7593198. 
  2. ^ a b c Li D, Desai-Yajnik V, Lo E, Schapira M, Abagyan R, Samuels HH (February 2000). "NRIF3 is a novel coactivator mediating functional specificity of nuclear hormone receptors". Mol Cell Biol 19 (10): 7191–202. PMC 84712. PMID 10490654. 
  3. ^ "Entrez Gene: ITGB3BP integrin beta 3 binding protein (beta3-endonexin)". 
  4. ^ Fujimoto TT, Katsutani S, Shimomura T, Fujimura K (January 2002). "Novel alternatively spliced form of beta(3)-endonexin". Thromb. Res. 105 (1): 63–70. doi:10.1016/s0049-3848(01)00405-4. PMID 11864709. 
  5. ^ Ohtoshi A, Maeda T, Higashi H, Ashizawa S, Yamada M, Hatakeyama M (January 2000). "beta3-endonexin as a novel inhibitor of cyclin A-associated kinase". Biochem. Biophys. Res. Commun. 267 (3): 947–52. doi:10.1006/bbrc.1999.2007. PMID 10673397. 
  6. ^ Besta F, Massberg S, Brand K, Müller E, Page S, Grüner S, Lorenz M, Sadoul K, Kolanus W, Lengyel E, Gawaz M (October 2002). "Role of beta(3)-endonexin in the regulation of NF-kappaB-dependent expression of urokinase-type plasminogen activator receptor". J. Cell. Sci. 115 (Pt 20): 3879–88. doi:10.1242/jcs.00081. PMID 12244126. 
  7. ^ a b Li D, Wang F, Samuels HH (December 2001). "Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation". Mol. Cell. Biol. 21 (24): 8371–84. doi:10.1128/MCB.21.24.8371-8384.2001. PMC 100002. PMID 11713274. 

Further reading[edit]