ITGB4

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Integrin, beta 4
Protein ITGB4 PDB 1qg3.png
PDB rendering based on 1qg3.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ITGB4 ; CD104
External IDs OMIM147557 MGI96613 HomoloGene179 GeneCards: ITGB4 Gene
RNA expression pattern
PBB GE ITGB4 204990 s at tn.png
PBB GE ITGB4 204989 s at tn.png
PBB GE ITGB4 211905 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3691 192897
Ensembl ENSG00000132470 ENSMUSG00000020758
UniProt P16144 A2A863
RefSeq (mRNA) NM_000213 NM_001005608
RefSeq (protein) NP_000204 NP_001005608
Location (UCSC) Chr 17:
73.72 – 73.75 Mb
Chr 11:
115.97 – 116.01 Mb
PubMed search [1] [2]

Integrin, beta 4 (ITGB4) also known as CD104 (Cluster of Differentiation 104), is a human gene.[1]

Integrins are heterodimers composed of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[1]

Interactions[edit]

ITGB4 has been shown to interact with Collagen, type XVII, alpha 1,[2][3] EIF6[4] and Erbin.[5]

See also[edit]

References[edit]

  1. ^ a b "Entrez Gene: ITGB4 integrin, beta 4". 
  2. ^ Aho, S; Uitto J (Feb 1998). "Direct interaction between the intracellular domains of bullous pemphigoid antigen 2 (BP180) and beta 4 integrin, hemidesmosomal components of basal keratinocytes". Biochem. Biophys. Res. Commun. (UNITED STATES) 243 (3): 694–9. doi:10.1006/bbrc.1998.8162. ISSN 0006-291X. PMID 9500991. 
  3. ^ Schaapveld, R Q; Borradori L; Geerts D; van Leusden M R; Kuikman I; Nievers M G; Niessen C M; Steenbergen R D; Snijders P J; Sonnenberg A (Jul 1998). "Hemidesmosome formation is initiated by the beta4 integrin subunit, requires complex formation of beta4 and HD1/plectin, and involves a direct interaction between beta4 and the bullous pemphigoid antigen 180". J. Cell Biol. (UNITED STATES) 142 (1): 271–84. doi:10.1083/jcb.142.1.271. ISSN 0021-9525. PMC 2133016. PMID 9660880. 
  4. ^ Biffo, S; Sanvito F; Costa S; Preve L; Pignatelli R; Spinardi L; Marchisio P C (Nov 1997). "Isolation of a novel beta4 integrin-binding protein (p27(BBP)) highly expressed in epithelial cells". J. Biol. Chem. (UNITED STATES) 272 (48): 30314–21. doi:10.1074/jbc.272.48.30314. ISSN 0021-9258. PMID 9374518. 
  5. ^ Favre, B; Fontao L; Koster J; Shafaatian R; Jaunin F; Saurat J H; Sonnenberg A; Borradori L (Aug 2001). "The hemidesmosomal protein bullous pemphigoid antigen 1 and the integrin beta 4 subunit bind to ERBIN. Molecular cloning of multiple alternative splice variants of ERBIN and analysis of their tissue expression". J. Biol. Chem. (United States) 276 (35): 32427–36. doi:10.1074/jbc.M011005200. ISSN 0021-9258. PMID 11375975. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.