From Wikipedia, the free encyclopedia
Jump to: navigation, search
Integrin, beta 7
Protein ITGB7 PDB 2brq.png
PDB rendering based on 2brq.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbol ITGB7
External IDs OMIM147559 MGI96616 HomoloGene20247 IUPHAR: 2461 ChEMBL: 2979 GeneCards: ITGB7 Gene
RNA expression pattern
PBB GE ITGB7 205718 at tn.png
More reference expression data
Species Human Mouse
Entrez 3695 16421
Ensembl ENSG00000139626 ENSMUSG00000001281
UniProt P26010 P26011
RefSeq (mRNA) NM_000889 NM_013566
RefSeq (protein) NP_000880 NP_038594
Location (UCSC) Chr 12:
53.59 – 53.6 Mb
Chr 15:
102.22 – 102.23 Mb
PubMed search [1] [2]

Integrin beta-7 is an integrin protein that in humans is encoded by the ITGB7 gene.[1][2] It can pair with ITGA4 (CD49d) to form the heterodimeric integrin receptor α4β7, or with ITGAE (CD103) to form αEβ7.[3]


Like all integrin subunits, β7 is a highly flexible, membrane-bound, extracellular protein that must pair with an α subunit for stability. The molecule's flexibility allows it to dynamically regulate its affinity for ligand through conformational changes.[4] Beginning with the apical end of the protein, farthest from the cell membrane, the β7 is composed of a head and upper legs, collectively known as the headpiece, lower legs, a transmembrane domain and a cytoplasmic tail. The top of the head is the I-like domain, sometimes called the βI domain, which, in combination with the α subunit, binds ligand. Just below this is the hybrid domain, a portion of which is N-terminal to the I-like domain. Below the hybrid domain is the PSI domain, which completes the headpiece. The lower legs consist of EGF domains 1-4 and the β tail domain. Finally there is a transmembrane domain, and the C-terminal cytoplasmic tail.[5]


ITGB7 has been shown to interact with EED.[6]


  1. ^ Erle DJ, Ruegg C, Sheppard D, Pytela R (Jul 1991). "Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes". J Biol Chem 266 (17): 11009–16. PMID 2040616. 
  2. ^ "Entrez Gene: ITGB7 integrin, beta 7". 
  3. ^ Byron A, Humphries JD, Askari JA, Craig SE, Mould AP, Humphries MJ (2009). "Anti-integrin monoclonal antibodies.". J Cell Sci 122 (Pt 22): 4009–11. doi:10.1242/jcs.056770. PMC 3329622. PMID 19910492. 
  4. ^ Carman CV, Springer TA (October 2003). "Integrin avidity regulation: are changes in affinity and conformation underemphasized?". Curr. Opin. Cell Biol. 15 (5): 547–56. doi:10.1016/ PMID 14519389. 
  5. ^ Yu Y, Zhu J, Mi LZ, Walz T, Sun H, Chen J, Springer TA (January 2012). "Structural specializations of α(4)β(7), an integrin that mediates rolling adhesion". J. Cell Biol. 196 (1): 131–46. doi:10.1083/jcb.201110023. PMC 3255974. PMID 22232704. 
  6. ^ Rietzler M, Bittner M, Kolanus W, Schuster A, Holzmann B (October 1998). "The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins". J. Biol. Chem. 273 (42): 27459–66. doi:10.1074/jbc.273.42.27459. PMID 9765275. 

Further reading[edit]

External links[edit]