ITGB7

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Integrin, beta 7
Protein ITGB7 PDB 2brq.png
PDB rendering based on 2brq.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbol ITGB7
External IDs OMIM147559 MGI96616 HomoloGene20247 ChEMBL: 2979 GeneCards: ITGB7 Gene
RNA expression pattern
PBB GE ITGB7 205718 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3695 16421
Ensembl ENSG00000139626 ENSMUSG00000001281
UniProt P26010 P26011
RefSeq (mRNA) NM_000889 NM_013566
RefSeq (protein) NP_000880 NP_038594
Location (UCSC) Chr 12:
53.59 – 53.6 Mb
Chr 15:
102.22 – 102.23 Mb
PubMed search [1] [2]

Integrin beta-7 is an integrin protein that in humans is encoded by the ITGB7 gene.[1][2] It can pair with ITGA4 (CD49d) to form the heterodimeric integrin receptor α4β7, or with ITGAE (CD103) to form αEβ7.[3]

Structure[edit]

Like all integrin subunits, β7 is a highly flexible, membrane-bound, extracellular protein that must pair with an α subunit for stability. The molecule's flexibility allows it to dynamically regulate its affinity for ligand through conformational changes.[4] Beginning with the apical end of the protein, farthest from the cell membrane, the β7 is composed of a head and upper legs, collectively known as the headpiece, lower legs, a transmembrane domain and a cytoplasmic tail. The top of the head is the I-like domain, sometimes called the βI domain, which, in combination with the α subunit, binds ligand. Just below this is the hybrid domain, a portion of which is N-terminal to the I-like domain. Below the hybrid domain is the PSI domain, which completes the headpiece. The lower legs consist of EGF domains 1-4 and the β tail domain. Finally there is a transmembrane domain, and the C-terminal cytoplasmic tail.[5]

Interactions[edit]

ITGB7 has been shown to interact with EED.[6]

References[edit]

  1. ^ Erle DJ, Ruegg C, Sheppard D, Pytela R (Jul 1991). "Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes". J Biol Chem 266 (17): 11009–16. PMID 2040616. 
  2. ^ "Entrez Gene: ITGB7 integrin, beta 7". 
  3. ^ Byron A, Humphries JD, Askari JA, Craig SE, Mould AP, Humphries MJ (2009). "Anti-integrin monoclonal antibodies.". J Cell Sci 122 (Pt 22): 4009–11. doi:10.1242/jcs.056770. PMC 3329622. PMID 19910492. 
  4. ^ Carman CV, Springer TA (October 2003). "Integrin avidity regulation: are changes in affinity and conformation underemphasized?". Curr. Opin. Cell Biol. 15 (5): 547–56. PMID 14519389. 
  5. ^ Yu Y, Zhu J, Mi LZ, Walz T, Sun H, Chen J, Springer TA (January 2012). "Structural specializations of α(4)β(7), an integrin that mediates rolling adhesion". J. Cell Biol. 196 (1): 131–46. doi:10.1083/jcb.201110023. PMC 3255974. PMID 22232704. 
  6. ^ Rietzler M, Bittner M, Kolanus W, Schuster A, Holzmann B (October 1998). "The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins". J. Biol. Chem. 273 (42): 27459–66. doi:10.1074/jbc.273.42.27459. PMID 9765275. 

Further reading[edit]

External links[edit]