ITGB8

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Integrin, beta 8
Identifiers
Symbol ITGB8
External IDs OMIM604160 MGI1338035 HomoloGene18567 GeneCards: ITGB8 Gene
RNA expression pattern
PBB GE ITGB8 211488 s at tn.png
PBB GE ITGB8 205816 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3696 320910
Ensembl ENSG00000105855 ENSMUSG00000025321
UniProt P26012 Q0VBD0
RefSeq (mRNA) NM_002214 NM_177290
RefSeq (protein) NP_002205 NP_796264
Location (UCSC) Chr 7:
20.37 – 20.46 Mb
Chr 12:
119.16 – 119.24 Mb
PubMed search [1] [2]

Integrin beta-8 is a protein that in humans is encoded by the ITGB8 gene.[1]

Function[edit]

This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.[1] Additionally, it has been shown to interact with RhoGDI1 to alter the activation of Rho GTPases to promote Glioblastoma cell invasiveness. Uncoupling the αvβ8-RhoGDI1 interaction has been seen to block GBM cell invasion by hyperactivating Rho GTPases.[2]

Clinical significance[edit]

High expression levels of ITGB8 are associated with high angiogenic and poorly invasive glioblastoma tumors. Conversely low expression of ITGB8 correlates with highly invasive but low angiogenic tumors.[3]

References[edit]

  1. ^ a b "Entrez Gene: ITGB8 integrin, beta 8". 
  2. ^ Reyes SB, Narayanan AS, Lee HS, Tchaicha JH, Aldape KD, Lang FF, Tolias KF, McCarty JH (January 2012). "αvβ8 Integrin Interacts with RhoGDI1 to Regulate Rac1 and Cdc42 Activation and Drive Glioblastoma Cell Invasion". Mol Bio Cell 24 (4): 474–82. doi:10.1091/mbc.E12-07-0521. PMID 23283986. 
  3. ^ Tchaicha JH, Reyes SB, Shin J, Hossain MG, Lang FF, McCarty JH (October 2011). "Glioblastoma Angiogenesis and Tumor Cell Invasiveness Are Differentially Regulated by {beta}8 Integrin". Cancer Res. 71 (20): 6371–81. doi:10.1158/0008-5472.CAN-11-0991. PMC 3193578. PMID 21859829. 

Further reading[edit]

External links[edit]