ITGB8
From Wikipedia, the free encyclopedia
| Integrin, beta 8 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | ITGB8; | ||||||||||||
| External IDs | OMIM: 604160 MGI: 1338035 HomoloGene: 18567 GeneCards: ITGB8 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 3696 | 320910 | |||||||||||
| Ensembl | ENSG00000105855 | ENSMUSG00000025321 | |||||||||||
| UniProt | P26012 | n/a | |||||||||||
| RefSeq (mRNA) | NM_002214 | NM_177290.3 | |||||||||||
| RefSeq (protein) | NP_002205 | NP_796264.2 | |||||||||||
| Location (UCSC) | Chr 7: 20.37 – 20.45 Mb |
Chr 12: 120.4 – 120.48 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Integrin beta-8 is a protein that in humans is encoded by the ITGB8 gene.[1]
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[edit] Function
This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.[1]
[edit] Clinical significance
High expression levels of ITGB8 correlates with high angiogenic and poorly invasive glioblastoma tumors. Conversely low expression of ITGB8 correlates with highly invasive but low angiogenic tumors.[2]
[edit] References
- ^ a b "Entrez Gene: ITGB8 integrin, beta 8". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3696.
- ^ Tchaicha JH, Reyes SB, Shin J, Hossain MG, Lang FF, McCarty JH (October 2011). "Glioblastoma Angiogenesis and Tumor Cell Invasiveness Are Differentially Regulated by {beta}8 Integrin". Cancer Res. 71 (20): 6371–81. doi:10.1158/0008-5472.CAN-11-0991. PMID 21859829.
[edit] Further reading
- Moyle M, Napier MA, McLean JW (1991). "Cloning and expression of a divergent integrin subunit beta 8.". J. Biol. Chem. 266 (29): 19650–8. PMID 1918072.
- Nishimura SL, Sheppard D, Pytela R (1994). "Integrin alpha v beta 8. Interaction with vitronectin and functional divergence of the beta 8 cytoplasmic domain.". J. Biol. Chem. 269 (46): 28708–15. PMID 7525578.
- Pilewski JM, Latoche JD, Arcasoy SM, Albelda SM (1997). "Expression of integrin cell adhesion receptors during human airway epithelial repair in vivo.". Am. J. Physiol. 273 (1 Pt 1): L256–63. PMID 9252563.
- "Toward a complete human genome sequence.". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
- Cambier S, Mu DZ, O'Connell D, et al. (2001). "A role for the integrin alphavbeta8 in the negative regulation of epithelial cell growth.". Cancer Res. 60 (24): 7084–93. PMID 11156415.
- Mu D, Cambier S, Fjellbirkeland L, et al. (2002). "The integrin αvβ8 mediates epithelial homeostasis through MT1-MMP–dependent activation of TGF-β1". J. Cell Biol. 157 (3): 493–507. doi:10.1083/jcb.200109100. PMC 2173277. PMID 11970960. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2173277.
- Jarad G, Wang B, Khan S, et al. (2003). "Fas activation induces renal tubular epithelial cell beta 8 integrin expression and function in the absence of apoptosis". J. Biol. Chem. 277 (49): 47826–33. doi:10.1074/jbc.M204901200. PMID 12324452.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2882961.
- Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
- Fjellbirkeland L, Cambier S, Broaddus VC, et al. (2003). "Integrin αvβ8-Mediated Activation of Transforming Growth Factor-β Inhibits Human Airway Epithelial Proliferation in Intact Bronchial Tissue". Am. J. Pathol. 163 (2): 533–42. doi:10.1016/S0002-9440(10)63681-4. PMC 1868219. PMID 12875973. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1868219.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Yan W, Shao R (2006). "Transduction of a mesenchyme-specific gene periostin into 293T cells induces cell invasive activity through epithelial-mesenchymal transformation". J. Biol. Chem. 281 (28): 19700–8. doi:10.1074/jbc.M601856200. PMID 16702213.
[edit] External links
- ITGB8 Info with links in the Cell Migration Gateway
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