From Wikipedia, the free encyclopedia
Jump to: navigation, search
Inter-alpha-trypsin inhibitor heavy chain 1
External IDs OMIM147270 MGI96618 HomoloGene1667 GeneCards: ITIH1 Gene
RNA expression pattern
PBB GE ITIH1 210888 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3697 16424
Ensembl ENSG00000055957 ENSMUSG00000006529
UniProt P19827 Q61702
RefSeq (mRNA) NM_001166434 NM_008406
RefSeq (protein) NP_001159906 NP_032432
Location (UCSC) Chr 3:
52.81 – 52.83 Mb
Chr 14:
30.93 – 30.94 Mb
PubMed search [1] [2]

Inter-alpha-trypsin inhibitor heavy chain H1 is a protein that in humans is encoded by the ITIH1 gene.[1][2][3]

See also[edit]


  1. ^ Salier JP, Simon D, Rouet P, Raguenez G, Muscatelli F, Gebhard W, Guenet JL, Mattei MG (Dec 1992). "Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily". Genomics 14 (1): 83–8. doi:10.1016/S0888-7543(05)80287-3. PMID 1385302. 
  2. ^ Jean L, Risler JL, Nagase T, Coulouarn C, Nomura N, Salier JP (May 1999). "The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair?". FEBS Lett 446 (1): 6–8. doi:10.1016/S0014-5793(99)00173-8. PMID 10100603. 
  3. ^ "Entrez Gene: ITIH1 inter-alpha (globulin) inhibitor H1". 

Further reading[edit]

  • Diarra-Mehrpour M, Bourguignon J, Bost F et al. (1992). "Human inter-alpha-trypsin inhibitor: full-length cDNA sequence of the heavy chain H1". Biochim. Biophys. Acta 1132 (1): 114–8. doi:10.1016/0167-4781(92)90065-8. PMID 1380832. 
  • Malki N, Balduyck M, Maes P et al. (1992). "The heavy chains of human plasma inter-alpha-trypsin inhibitor: their isolation, their identification by electrophoresis and partial sequencing. Differential reactivity with concanavalin A". Biol. Chem. Hoppe-Seyler 373 (10): 1009–18. doi:10.1515/bchm3.1992.373.2.1009. PMID 1384548. 
  • Salier JP, Diarra-Mehrpour M, Sesboue R et al. (1988). "Isolation and characterization of cDNAs encoding the heavy chain of human inter-alpha-trypsin inhibitor (I alpha TI): unambiguous evidence for multipolypeptide chain structure of I alpha TI". Proc. Natl. Acad. Sci. U.S.A. 84 (23): 8272–6. doi:10.1073/pnas.84.23.8272. PMC 299524. PMID 2446322. 
  • Diarra-Mehrpour M, Bourguignon J, Sesboüé R et al. (1989). "Human plasma inter-alpha-trypsin inhibitor is encoded by four genes on three chromosomes". Eur. J. Biochem. 179 (1): 147–54. doi:10.1111/j.1432-1033.1989.tb14532.x. PMID 2465147. 
  • Gebhard W, Schreitmüller T, Hochstrasser K, Wachter E (1989). "Two out of the three kinds of subunits of inter-alpha-trypsin inhibitor are structurally related". Eur. J. Biochem. 181 (3): 571–6. doi:10.1111/j.1432-1033.1989.tb14762.x. PMID 2471637. 
  • Enghild JJ, Thøgersen IB, Pizzo SV, Salvesen G (1989). "Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan". J. Biol. Chem. 264 (27): 15975–81. PMID 2476436. 
  • Schreitmüller T, Hochstrasser K, Reisinger PW et al. (1987). "cDNA cloning of human inter-alpha-trypsin inhibitor discloses three different proteins". Biol. Chem. Hoppe-Seyler 368 (8): 963–70. doi:10.1515/bchm3.1987.368.2.963. PMID 3663330. 
  • Huang L, Yoneda M, Kimata K (1994). "A serum-derived hyaluronan-associated protein (SHAP) is the heavy chain of the inter alpha-trypsin inhibitor". J. Biol. Chem. 268 (35): 26725–30. PMID 7504674. 
  • Bost F, Bourguignon J, Martin JP et al. (1994). "Isolation and characterization of the human inter-alpha-trypsin inhibitor heavy-chain H1 gene". Eur. J. Biochem. 218 (2): 283–91. doi:10.1111/j.1432-1033.1993.tb18376.x. PMID 7505744. 
  • Morelle W, Capon C, Balduyck M et al. (1994). "Chondroitin sulphate covalently cross-links the three polypeptide chains of inter-alpha-trypsin inhibitor". Eur. J. Biochem. 221 (2): 881–8. doi:10.1111/j.1432-1033.1994.tb18803.x. PMID 7513643. 
  • Diarra-Mehrpour M, Bourguignon J, Sarafan N et al. (1994). "Tandem orientation of the inter-alpha-trypsin inhibitor heavy chain H1 and H3 genes". Biochim. Biophys. Acta 1219 (2): 551–4. doi:10.1016/0167-4781(94)90087-6. PMID 7522574. 
  • Ding M, Umetsu K, Yuasa I et al. (1995). "Molecular basis of inter-alpha-trypsin inhibitor heavy chain H1 (ITIH1) polymorphism". Hum. Genet. 95 (4): 435–6. doi:10.1007/BF00208970. PMID 7535743. 
  • Zhao M, Yoneda M, Ohashi Y et al. (1995). "Evidence for the covalent binding of SHAP, heavy chains of inter-alpha-trypsin inhibitor, to hyaluronan". J. Biol. Chem. 270 (44): 26657–63. doi:10.1074/jbc.270.44.26657. PMID 7592891. 
  • Bourguignon J, Diarra-Mehrpour M, Thiberville L et al. (1993). "Human pre-alpha-trypsin inhibitor-precursor heavy chain. cDNA and deduced amino-acid sequence". Eur. J. Biochem. 212 (3): 771–6. doi:10.1111/j.1432-1033.1993.tb17717.x. PMID 7681778. 
  • Olsen EH, Rahbek-Nielsen H, Thogersen IB et al. (1998). "Posttranslational modifications of human inter-alpha-inhibitor: identification of glycans and disulfide bridges in heavy chains 1 and 2". Biochemistry 37 (1): 408–16. doi:10.1021/bi971137d. PMID 9425062. 
  • Flahaut C, Capon C, Balduyck M et al. (1998). "Glycosylation pattern of human inter-alpha-inhibitor heavy chains". Biochem. J. 333 ( Pt 3) (Pt 3): 749–56. PMC 1219641. PMID 9677337. 
  • Flahaut C, Mizon C, Aumercier-Maes P et al. (1998). "Disulphide bonds assignment in the inter-alpha-inhibitor heavy chains--structural and functional implications". Eur. J. Biochem. 255 (1): 107–15. doi:10.1046/j.1432-1327.1998.2550107.x. PMID 9692908. 
  • Diarra-Mehrpour M, Sarafan N, Bourguignon J et al. (1998). "Human inter-alpha-trypsin inhibitor heavy chain H3 gene. Genomic organization, promoter analysis, and gene linkage". J. Biol. Chem. 273 (41): 26809–19. doi:10.1074/jbc.273.41.26809. PMID 9756925.