ITIH2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Inter-alpha-trypsin inhibitor heavy chain 2
Identifiers
Symbols ITIH2 ; H2P; SHAP
External IDs OMIM146640 MGI96619 HomoloGene1668 GeneCards: ITIH2 Gene
RNA expression pattern
PBB GE ITIH2 204987 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3698 16425
Ensembl ENSG00000151655 ENSMUSG00000037254
UniProt P19823 Q61703
RefSeq (mRNA) NM_002216 NM_010582
RefSeq (protein) NP_002207 NP_034712
Location (UCSC) Chr 10:
7.75 – 7.79 Mb
Chr 2:
10.09 – 10.13 Mb
PubMed search [1] [2]

Inter-alpha-trypsin inhibitor heavy chain H2 is a protein that in humans is encoded by the ITIH2 gene.[1][2][3]

It is known to contain a Gla domain, and thus be dependent for production on post translational modification requiring vitamin K. Its function is also presumably dependent on calcium ions.

See also[edit]

References[edit]

  1. ^ Salier JP, Simon D, Rouet P, Raguenez G, Muscatelli F, Gebhard W, Guenet JL, Mattei MG (Dec 1992). "Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily". Genomics 14 (1): 83–8. doi:10.1016/S0888-7543(05)80287-3. PMID 1385302. 
  2. ^ Jean L, Risler JL, Nagase T, Coulouarn C, Nomura N, Salier JP (May 1999). "The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair?". FEBS Lett 446 (1): 6–8. doi:10.1016/S0014-5793(99)00173-8. PMID 10100603. 
  3. ^ "Entrez Gene: ITIH2 inter-alpha (globulin) inhibitor H2". 

Further reading[edit]