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Inter-alpha-trypsin inhibitor heavy chain 2
Symbols ITIH2 ; H2P; SHAP
External IDs OMIM146640 MGI96619 HomoloGene1668 GeneCards: ITIH2 Gene
RNA expression pattern
PBB GE ITIH2 204987 at tn.png
More reference expression data
Species Human Mouse
Entrez 3698 16425
Ensembl ENSG00000151655 ENSMUSG00000037254
UniProt P19823 Q61703
RefSeq (mRNA) NM_002216 NM_010582
RefSeq (protein) NP_002207 NP_034712
Location (UCSC) Chr 10:
7.75 – 7.79 Mb
Chr 2:
10.09 – 10.13 Mb
PubMed search [1] [2]

Inter-alpha-trypsin inhibitor heavy chain H2 is a protein that in humans is encoded by the ITIH2 gene.[1][2][3]

It is known to contain a Gla domain, and thus be dependent for production on post translational modification requiring vitamin K. Its function is also presumably dependent on calcium ions.

See also[edit]


  1. ^ Salier JP, Simon D, Rouet P, Raguenez G, Muscatelli F, Gebhard W, Guenet JL, Mattei MG (Dec 1992). "Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily". Genomics 14 (1): 83–8. doi:10.1016/S0888-7543(05)80287-3. PMID 1385302. 
  2. ^ Jean L, Risler JL, Nagase T, Coulouarn C, Nomura N, Salier JP (May 1999). "The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair?". FEBS Lett 446 (1): 6–8. doi:10.1016/S0014-5793(99)00173-8. PMID 10100603. 
  3. ^ "Entrez Gene: ITIH2 inter-alpha (globulin) inhibitor H2". 

Further reading[edit]