ITK (gene)

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IL2-inducible T-cell kinase
PBB Protein ITK image.jpg
1LUI
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ITK ; EMT; LPFS1; LYK; PSCTK2
External IDs OMIM186973 MGI96621 HomoloGene4051 ChEMBL: 2959 GeneCards: ITK Gene
EC number 2.7.10.2
RNA expression pattern
PBB GE ITK 211339 s at tn.png
More reference expression data
Protein domains
Q08881 ProteinDomains SMART.png
Orthologs
Species Human Mouse
Entrez 3702 16428
Ensembl ENSG00000113263 ENSMUSG00000020395
UniProt Q08881 Q03526
RefSeq (mRNA) NM_005546 NM_001281965
RefSeq (protein) NP_005537 NP_001268894
Location (UCSC) Chr 5:
156.57 – 156.68 Mb
Chr 11:
46.33 – 46.39 Mb
PubMed search [1] [2]

Tyrosine-protein kinase ITK/TSK also known as interleukin-2-inducible T-cell kinase or simply ITK, is a protein that in humans is encoded by the ITK gene.[1] ITK is a member of the TEC family of kinases and is highly expressed in T cells. [2]

Function[edit]

This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein is thought to play a role in T-cell proliferation and differentiation.[3][4] ITK is functionally important for the development and effector function of Th2 and Th17 cells. [2]

Structure[edit]

This protein contains the following domains, which are often found in intracellular kinases:[5]

Interactions[edit]

ITK (gene) has been shown to interact with:

References[edit]

  1. ^ Gibson S, Leung B, Squire JA, Hill M, Arima N, Goss P, Hogg D, Mills GB (September 1993). "Identification, cloning, and characterization of a novel human T-cell-specific tyrosine kinase located at the hematopoietin complex on chromosome 5q". Blood 82 (5): 1561–72. PMID 8364206. 
  2. ^ a b Gomez-Rodriguez J, Kraus ZJ, Schwartzberg PL (March 2011). "Tec family kinases Itk and Rlk / Txk in T lymphocytes: cross-regulation of cytokine production and T-cell fates.". FEBS 278 (12): 1980–1989. doi:10.1111/j.1742-4658.2011.08072.x. PMC 3117960. PMID 21362139. 
  3. ^ Kosaka Y, Felices M, Berg LJ (October 2006). "Itk and Th2 responses: action but no reaction". Trends Immunol. 27 (10): 453–60. doi:10.1016/j.it.2006.08.006. PMID 16931156. 
  4. ^ "Entrez Gene: ITK IL2-inducible T-cell kinase". 
  5. ^ Hawkins J, Marcy A (July 2001). "Characterization of Itk tyrosine kinase: contribution of noncatalytic domains to enzymatic activity". Protein Expr. Purif. 22 (2): 211–9. doi:10.1006/prep.2001.1447. PMID 11437596. 
  6. ^ a b c Bunnell SC, Diehn M, Yaffe MB, Findell PR, Cantley LC, Berg LJ (2000). "Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade". J. Biol. Chem. 275 (3): 2219–30. doi:10.1074/jbc.275.3.2219. PMID 10636929. 
  7. ^ a b c Bunnell SC, Henry PA, Kolluri R, Kirchhausen T, Rickles RJ, Berg LJ (1996). "Identification of Itk/Tsk Src homology 3 domain ligands". J. Biol. Chem. 271 (41): 25646–56. doi:10.1074/jbc.271.41.25646. PMID 8810341. 
  8. ^ a b Andreotti AH, Bunnell SC, Feng S, Berg LJ, Schreiber SL (1997). "Regulatory intramolecular association in a tyrosine kinase of the Tec family". Nature 385 (6611): 93–7. doi:10.1038/385093a0. PMID 8985255. 
  9. ^ a b Hao S, August A (2002). "The proline rich region of the Tec homology domain of ITK regulates its activity". FEBS Lett. 525 (1-3): 53–8. doi:10.1016/S0014-5793(02)03066-1. PMID 12163161. 
  10. ^ Perez-Villar JJ, O'Day K, Hewgill DH, Nadler SG, Kanner SB (2001). "Nuclear localization of the tyrosine kinase Itk and interaction of its SH3 domain with karyopherin alpha (Rch1alpha)". Int. Immunol. 13 (10): 1265–74. doi:10.1093/intimm/13.10.1265. PMID 11581171. 
  11. ^ Shan X, Wange RL (1999). "Itk/Emt/Tsk activation in response to CD3 cross-linking in Jurkat T cells requires ZAP-70 and Lat and is independent of membrane recruitment". J. Biol. Chem. 274 (41): 29323–30. doi:10.1074/jbc.274.41.29323. PMID 10506192. 
  12. ^ Perez-Villar JJ, Whitney GS, Sitnick MT, Dunn RJ, Venkatesan S, O'Day K, Schieven GL, Lin TA, Kanner SB (2002). "Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav". Biochemistry 41 (34): 10732–40. doi:10.1021/bi025554o. PMID 12186560. 
  13. ^ Shim EK, Moon CS, Lee GY, Ha YJ, Chae SK, Lee JR (2004). "Association of the Src homology 2 domain-containing leukocyte phosphoprotein of 76 kD (SLP-76) with the p85 subunit of phosphoinositide 3-kinase". FEBS Lett. 575 (1-3): 35–40. doi:10.1016/j.febslet.2004.07.090. PMID 15388330. 
  14. ^ Perez-Villar JJ, Kanner SB (1999). "Regulated association between the tyrosine kinase Emt/Itk/Tsk and phospholipase-C gamma 1 in human T lymphocytes". J. Immunol. 163 (12): 6435–41. PMID 10586033. 
  15. ^ Brazin KN, Mallis RJ, Fulton DB, Andreotti AH (2002). "Regulation of the tyrosine kinase Itk by the peptidyl-prolyl isomerase cyclophilin A". Proc. Natl. Acad. Sci. U.S.A. 99 (4): 1899–904. doi:10.1073/pnas.042529199. PMC 122291. PMID 11830645. 
  16. ^ Cory GO, MacCarthy-Morrogh L, Banin S, Gout I, Brickell PM, Levinsky RJ, Kinnon C, Lovering RC (1996). "Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways". J. Immunol. 157 (9): 3791–5. PMID 8892607. 

Further reading[edit]