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Intersectin 2
Protein ITSN2 PDB 1j3t.png
PDB rendering based on 1j3t.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ITSN2 ; PRO2015; SH3D1B; SH3P18; SWA; SWAP
External IDs OMIM604464 MGI1338049 HomoloGene22627 GeneCards: ITSN2 Gene
RNA expression pattern
PBB GE ITSN2 209907 s at tn.png
More reference expression data
Species Human Mouse
Entrez 50618 20403
Ensembl ENSG00000198399 ENSMUSG00000020640
UniProt Q9NZM3 B2RR82
RefSeq (mRNA) NM_006277 NM_001198968
RefSeq (protein) NP_006268 NP_001185897
Location (UCSC) Chr 2:
24.2 – 24.36 Mb
Chr 12:
4.59 – 4.71 Mb
PubMed search [1] [2]

Intersectin-2 is a protein that in humans is encoded by the ITSN2 gene.[1][2][3]

This gene encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis. Alternatively spliced transcript variants have been found for this gene that encode three distinct isoforms. Additional variants have been found but their full length nature has not been determined.[3]


ITSN2 has been shown to interact with Wiskott-Aldrich syndrome protein.[2]


  1. ^ Pucharcos C, Estivill X, de la Luna S (Aug 2000). "Intersectin 2, a new multimodular protein involved in clathrin-mediated endocytosis". FEBS Lett 478 (1–2): 43–51. doi:10.1016/S0014-5793(00)01793-2. PMID 10922467. 
  2. ^ a b McGavin MK, Badour K, Hardy LA, Kubiseski TJ, Zhang J, Siminovitch KA (Dec 2001). "The intersectin 2 adaptor links Wiskott Aldrich Syndrome protein (WASp)-mediated actin polymerization to T cell antigen receptor endocytosis". J Exp Med 194 (12): 1777–87. doi:10.1084/jem.194.12.1777. PMC 2193569. PMID 11748279. 
  3. ^ a b "Entrez Gene: ITSN2 intersectin 2". 

Further reading[edit]