The LP was released on September 11, 1969 and reached gold record status within two months of its release. It was issued by Columbia under #KCS 9913. The first pressing was titled only on the spine and disc labels. Later, the title of the album was added as a sticker on cellophane tape designed by R. Crumb and stuck to the cellophane sealed wrapping. The album was re-released by Columbia as WKPC 9913 and again as PC 9913 both on vinyl. The re-issued album did not have the same title sticker, instead the re-issues had the title printed on the cover and the Sony's "Nice Price" sticker on the wrapping. Some of the newer PC 9913 have a bar code. A 180 Gram Limited Edition classic LP high-definition Virgin Heavy Vinyl pressing was also released in 2010. Technically, this album was reissued on vinyl a total of six times. Many collectors are mistaken in thinking the issue that included the R. Crumb sticker was the original issue, it was not. The hard to find original sealed issue is KCS 9913, which had no R. Crumb sticker, and the title was only on the spine of the cover. Columbia Records released as a single Kozmic Blues b/w Little Girl Blue 4-45023, the single peaked at #41 on the US Billboard charts
I Got Dem Ol' Kozmic Blues Again Mama! also contains the hits "Try (Just A Little Bit Harder)", "Kozmic Blues" and "To Love Somebody". The CD reissue of the album additionally includes the outtake cover of Bob Dylan's "Dear Landlord", with new lyrics and arrangements provided by Joplin, and versions of "Summertime" and "Piece of My Heart" recorded live at Woodstock as bonus tracks.
According to critic Richie Unterberger, the album was poorly reviewed on its initial release, due in part to its shift towards soul/R&B and away from the hard rock/psychedelic sound that brought her to fame with Big Brother and the Holding Company. Over the decades, Unterberger notes that opinions of the album have warmed somewhat and that taken on its own merits the album has its strengths, but he nonetheless describes it as a "flawed" effort due in part to the backing musicians sounding "a little stiff".