Richard Burrows is a medical student with a pregnant wife, Jody, who becomes unappealing to him before and after childbirth, abstaining from sex and gaining weight. When her mother moves in with them, Richard's home life frustrates him even more.
Flirtations with nurses and patients begin, with Jody catching him being unfaithful. But after he becomes a surgeon at a Los Angeles hospital, the infidelity continues. Richard meets a married model, Helene Donnelly, and begins meeting her secretly in motels. They contemplate getting divorces.
Richard decides to make one last attempt to save his marriage. He evicts his mother-in-law from the premises and persuades Jody to go to a weight-loss center. When his wife returns, she is slim again and Richard is pleased, until learning that now it is she who wants a divorce.