Ibogamine

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Ibogamine
Ibogamine.svg
Systematic (IUPAC) name
[6R-(6α,6aβ,7β,9α)]-7-ethyl-6,6a,7,8,9,10,12,13-octahydro-6,9-methano-5H-pyrido[1',2':1,2]azepino[4,5-b]indole
Clinical data
Identifiers
481-87-8 N
None
PubChem CID 100217
ChemSpider 90568 YesY
ChEBI CHEBI:5853 YesY
Chemical data
Formula C19H24N2
280.41 g/mol
 N (what is this?)  (verify)

Ibogamine is an alkaloid found in Tabernanthe iboga.[1][2]

Basic research related to how addiction affects the brain has used this chemical.[3]

Ibogamine persistently reduced the self-administration of cocaine and morphine in rats.[4]

See also[edit]

References[edit]

  1. ^ Bartlett, M. F.; Dickel, D. F.; Taylor, W. I. (1958). "The Alkaloids of Tabernanthe iboga. Part IV.1 The Structures of Ibogamine, Ibogaine, Tabernanthine and Voacangine - Journal of the American Chemical Society (ACS Publications)". Journal of the American Chemical Society 80 (1): 126. doi:10.1021/ja01534a036. 
  2. ^ Kuehne, Martin E.; Reider, Paul J. (1985). "A synthesis of ibogamine - The Journal of Organic Chemistry (ACS Publications)". The Journal of Organic Chemistry 50 (9): 1464. doi:10.1021/jo00209a020. 
  3. ^ Levi MS, Borne RF (October 2002). "A review of chemical agents in the pharmacotherapy of addiction". Curr. Med. Chem. 9 (20): 1807–18. PMID 12369879. 
  4. ^ Glick SD, Kuehne ME, Raucci J, Wilson TE, Larson D, Keller RW Jr, Carlson JN (September 1994). "Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum.". Brain Res. 657 (1-2): 14–22. doi:10.1016/0006-8993(94)90948-2. PMID 7820611.