Born as Igor Cassini Loiewski, he also worked as a publicist, ran the Celebrity Register, edited a short-lived magazine called Status, was a co-director of the fashion company House of Cassini, founded by his elder brother, Oleg Cassini, and was a television personality in the 1950s and 1960s.
Cassini's first attention at a national level was achieved in the Summer of 1939 when, as a result of a column he wrote that upset members of Virginia high society, he was kidnapped, tarred and feathered by a trio of locals near Warrenton, Virginia. Cassini himself later reflected, "From an obscure junior society columnist always worried as to how I would ever find enough material to fill the space I was grudgingly given, I became national news overnight." 
Cassini's height of influence was in the 1950s, when the Hearst chain claimed 20,000,000 readership for papers that carried his column. He coined the term "Jet set" to described the global movements of what had been "café society" — those who entertained at restaurants and night clubs and hobnobbed with the stars of the entertainment industry. His pen name evoked the fictional quintessential New Yorker, "Diedrich Knickerbocker", who was created by Washington Irving. The term "café society" had been invented by Maury Paul, Cassini's predecessor as "Cholly Knickerbocker" at the New York Journal American.
Later in his career, Igor, who was known as "Ghighi", hired a young assistant from Texas named Liz Smith. He also was the host of The Igor Cassini Show, an interview program that aired on the DuMont Television Network from October 25, 1953 to February 28, 1954, as well as another television program, Igor Cassini's Million Dollar Showcase.
His autobiography, co-written with Jeanne Molli, I'd Do It All Over Again: The Life and Times of Igor Cassini, appeared in 1977 (ISBN 0-399-11553-6).
Family and childhood
He was born in Sevastopol, Russia, now Ukraine, and his elder brother, Oleg Cassini, became a fashion designer best known for dressing First Lady Jacqueline Kennedy. They were the sons of Countess Marguerite Cassini, an Italian-Russian aristocrat, and her husband, Alexander Loiewski, a Russian diplomat. His maternal grandfather, Arthur Paul Nicholas Cassini, Marquis de Capuzzuchi di Bologna, Count Cassini, was the Russian ambassador to the United States during the administrations of William McKinley and Theodore Roosevelt (see ).
Cassini's father later adopted his wife's surname, which they deemed more distinguished, and when the family lost its status and fortune in the wake of the Russian Revolution of 1917, the family moved to Italy, where Marguerite Cassini went to work as a fashion designer. Igor Cassini Loiewski was raised in Italy, and moved to the United States in 1936 with his parents and elder brother.
His first marriage, in 1940, was to Austine Byrne McDonnell (1920–1991), a Hearst journalist known as "The Most Magnificent Doll Among American Newspaperwomen". She also screentested for the role of Melanie Wilkes in the motion picture Gone with the Wind. At the time of their marriage, they both worked for the Washington Times-Herald. They had no children. Known as Bootsie, she divorced him in 1947 and the next year became the third wife of William Randolph Hearst, Jr. During and after her marriage to Cassini, she wrote "These Charming People", the society column of Washington Times-Herald, under the bylines Austine Cassini and Austine.
His second wife was Elizabeth Darrah Waters whom he married in 1948 and divorced in 1952. They had one daughter, Marina.
His third wife, whom he married in 1952, was Charlene Stafford Wrightsman (1927–1963), the younger daughter of Charles B. Wrightsman, an oil millionaire whose collection of French and Austrian furniture — much of which was acquired through the designers Denning & Fourcade — and decorative arts fills several galleries at the Metropolitan Museum. She was previously married (1947–1950) to the actor Helmut Dantine, by whom she had a son, Dana Wrightsman Dantine. She and Cassini had one son, Alexander.
On April 8, 1963, while in her bedroom, with her 14-year-old stepdaughter, Marina Cassini, by her side, as the teenager watched the 35th Academy Awards on television, Charlene Cassini swallowed 30 sleeping pills and died the next day. She reportedly was distraught after Attorney General Robert F. Kennedy had indicted her husband for failing to register under the U.S. Registration Act, as an agent of a foreign government (a public relations agency he helped found, Martial & Company, had taken on the Dominican Republic as a client). She also suffered from headaches following a minor household accident, was depressed after the suicide of a ski instructor friend, and had become bitterly estranged from her father.
After his wife's death, Cassini later wrote, "We discovered the apartment, particularly her closets, littered with all kinds of pills, hidden in vases, under linens, stuffed in her shoes and the pockets of her clothes."
Cassini's fourth wife was the actress Gianna Lou Müller, better known as Nadia Cassini, whom he married in 1969 and divorced in 1972.
His fifth wife was Brenda Mitchell, a top fashion model, from whom he also was divorced. They had two sons, Nicholas, formerly a professional golfer on the Nationwide Tour and Dimitri, who is involved in international real estate.
He died in New York City, aged 86, from natural causes.
- New York Times: Igor Cassini, Hearst Columnist, Dies at 86, retrieved 2012-06-24
-  David Patrick Columbia, "New York Social Diary": "The List"
- New York Times obituary: "Igor Cassini, Hearst Columnist, Dies at 86", 1/9/02 N.Y. Times B8, available on Westlaw at 2002 WLNR 4070560.