Imipraminoxide

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Imipraminoxide
Imipraminoxide skeletal.svg
Systematic (IUPAC) name
3-(5,6-dihydrobenzo[b][f]benzazepin- 11-yl)- N,N-dimethyl- propan- 1-amine N-oxide
Clinical data
Legal status
  • Prescription only
Routes oral
Identifiers
CAS number 6829-98-7
ATC code N06AA03
PubChem CID 65589
ChemSpider 59031
UNII 8MKS280XJW YesY
KEGG D07334
Chemical data
Formula C19H24N2O 
Mol. mass 296.41 g/mol

Imipraminoxide (Imiprex, Elepsin), or imipramine N-oxide, is a tricyclic antidepressant (TCA) that was introduced in Europe in the 1960s for the treatment of depression.[1][2][3][4]

Imipraminoxide is both an analogue and a metabolite of imipramine, and has similar effects.[5][6][7][8] However, in clinical trials, imipraminoxide was found to have a faster onset of action, slightly higher efficacy, and fewer and less marked side effects, including diminished orthostatic hypotension and anticholinergic effects like dry mouth, sweating, dizziness, and fatigue.[5][6][7][8][9][10]

Imipraminoxide's pharmacology has not been well elucidated, but based on its very close relationship with imipramine, it likely acts as a serotonin and norepinephrine reuptake inhibitor and serotonin, adrenenaline, histamine, and muscarinic acetylcholine receptor antagonist, though with weaker antiadrenergic and anticholinergic actions.[9][10]

See also[edit]

References[edit]

  1. ^ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. p. 546. ISBN 3-88763-075-0. 
  2. ^ Dictionary of organic compounds. London: Chapman & Hall. 1996. p. 3877. ISBN 0-412-54090-8. 
  3. ^ FAURBYE A, JACOBSEN O, KRISTJANSEN P, MUNKVAD I (September 1963). "Imipramine-N-oxide: preliminary investigation of a new antidepressive drug". The American Journal of Psychiatry 120: 277–8. PMID 13944543. 
  4. ^ Lingjaerde O (November 1971). "[Imiprex "Dumex" (imipramine oxide). A new tricyclic antidepressive agent]". Tidsskrift for Den Norske Lægeforening : Tidsskrift for Praktisk Medicin, Ny Række (in Norwegian) 91 (31): 2267–8. PMID 5133241. 
  5. ^ a b Rapp W, Norén MB, Pedersen F (1973). "Comparative trial of imipramine N-oxide and imipramine in the treatment of out-patients with depressive syndromes". Acta Psychiatrica Scandinavica 49 (1): 77–90. doi:10.1111/j.1600-0447.1973.tb04400.x. PMID 4572170. 
  6. ^ a b Aronson, Jeffrey Kenneth (2008). Meyler's Side Effects of Psychiatric Drugs (Meylers Side Effects). Amsterdam: Elsevier Science. p. 34. ISBN 0-444-53266-8. 
  7. ^ a b Dencker SJ (1971). "[Clinical trial with imipramine-N-oxide and amitriptyline-N-oxide]". Nordisk Psykiatrisk Tidsskrift. Nordic Journal of Psychiatry (in Swedish) 25 (5): 463–70. PMID 4947298. 
  8. ^ a b Beale, John Marlowe; Wilson, Charles Henry; Gisvold, Ole; Block, John H. (2004). Wilson and Gisvold's textbook of organic medicinal and pharmaceutical chemistry. Hagerstwon, MD: Lippincott Williams & Wilkins. p. 87. ISBN 0-7817-3481-9. 
  9. ^ a b Dencker SJ, Bake B (July 1976). "Investigation of the orthostatic reaction after intravenous administration of imipramine, chlorimipramine, and inimpramine-N-oxide". Acta Psychiatrica Scandinavica 54 (1): 74–8. doi:10.1111/j.1600-0447.1976.tb00095.x. PMID 952235. 
  10. ^ a b Clemmesen L, Mikkelsen PL, Lund H, Bolwig TG, Rafaelsen OJ (1984). "Assessment of the anticholinergic effects of antidepressants in a single-dose cross-over study of salivation and plasma levels". Psychopharmacology 82 (4): 348–54. doi:10.1007/BF00427684. PMID 6427827.