Immune disorder

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Immune disorder
Classification and external resources
ICD-10 D80-D89
ICD-9 273, 279
MeSH D007154

An immune disorder is a dysfunction of the immune system. These disorders can be characterized in several different ways:

  • By the component(s) of the immune system affected
  • By whether the immune system is overactive or underactive
  • By whether the condition is congenital or acquired

According to the International Union of Immunological Societies, more than 150 primary immunodeficiency diseases (PIDs) have been characterized.[1] However, the number of acquired immunodeficiencies exceeds the number of PIDs.[2]

It has been suggested that most people have at least one primary immunodeficiency.[3] Due to redundancies in the immune system, though, many of these are never detected.

List of some autoimmune disorders[edit]

Main article: autoimmune disorders

Immunodeficiencies[edit]

Main article: immunodeficiency

Primary immune deficiency diseases are those caused by inherited genetic mutations. Secondary or acquired immune deficiencies are caused by something outside the body such as a virus or immune suppressing drugs.[4]

Primary immune diseases are at risk to an increased susceptibility to, and often recurrent ear infections, pneumonia, bronchitis, sinusitis or skin infections. Immunodeficient patients may less frequently develop abscesses of their internal organs, autoimmune or rheumatologic and gastrointestinal problems.[5]

Primary immune deficiencies
Secondary immune deficiencies

Allergies[edit]

Main article: allergy

An allergy is an abnormal immune reaction to a harmless antigen.

See also[edit]

References[edit]

  1. ^ Geha RS, Notarangelo LD, Casanova JL et al. (October 2007). "Primary immunodeficiency diseases: an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee". J. Allergy Clin. Immunol. 120 (4): 776–94. doi:10.1016/j.jaci.2007.08.053. PMC 2601718. PMID 17952897. 
  2. ^ Kumar A, Teuber SS, Gershwin ME (2006). "Current perspectives on primary immunodeficiency diseases". Clin. Dev. Immunol. 13 (2–4): 223–59. doi:10.1080/17402520600800705. PMC 2270780. PMID 17162365. 
  3. ^ Casanova JL, Abel L (August 2007). "Primary immunodeficiencies: a field in its infancy". Science 317 (5838): 617–9. doi:10.1126/science.1142963. PMID 17673650. 
  4. ^ "Primary Immune Deficiency Diseases". Department of Health and Human Services: National Institutes of Health. Retrieved 31 August 2011. 
  5. ^ "Primary Immunodeficiency FAQ". INFO4PI. Retrieved 31 August 2011. 
  6. ^ http://www.merckmanuals.com/home/immune_disorders.html

External links[edit]