Immunophilins

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In molecular biology, immunophilins are endogenous cytosolic peptidyl-prolyl isomerases that interconvert between the cis and trans positions.

Immunophilins are targeted by immunosuppressive drugs such as rapamycin, ciclosporin, and tacrolimus. For these drugs in particular, known immunophilins such as cyclophilin catalyze the cis-trans isomerization of peptide bonds, particularly X-Pro peptide bonds. This isomerase activity can be inhibited by immunosuppressive drugs.

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Transmembrane receptors: Immunoglobulin superfamily immune receptors

Antibody receptor:
Fc receptor

Epsilon (ε)	FcεRI · (FcεRII is C-type lectin)

Gamma (γ)	FcγRI · FcγRII · FcγRIII · Neonatal

Alpha (α)/mu (μ)	FcαRI · Fcα/μR

Secretory	Polymeric immunoglobulin receptor

Antigen receptor

B cells

Antigen receptor	BCR

Co-receptor	stimulate: CD21/CD19/CD81 inhibit: CD22

Accessory molecules	Ig-α/Ig-β (CD79)

T cells

Ligands	MHC (MHC class I and MHC class II)

Antigen receptor	TCR: TRA@ · TRB@ · TRD@ · TRG@

Co-receptors	CD8 (with two glycoprotein chains CD8α and CD8β) · CD4

Accessory molecules	CD3 · CD3γ · CD3δ · CD3ε · ζ-chain (also called CD3ζ and TCRζ)

Cytokine receptor

see cytokine receptors

Killer-cell IG-like receptors

KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DL5B, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KIR3DS1

Leukocyte IG-like receptors

LILRA1 · LILRA2 · LILRA3 · LILRA4 · LILRA5 · LILRA6 · LILRB1 · LILRB2 · LILRB3 · LILRB4 · LILRB5 · LILRA6 · LILRA5

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)