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In extremis or extremis may refer to:
- In extremis, a Latin phrase meaning "in the farthest reaches" or "at the point of death"
- In Extremis (Days Between Stations album), 2013
- In Extremis (Thinking Plague album), 1998
- In extremis (film), a 2000 film by Etienne Faure
- In Extremis (play), a 2006 play by Howard Brenton
- "Extremis", an Iron Man story arc
- Extremis: Drop Ride to Doom, an attraction at the London Dungeon
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