SR 650 begins at a four-way intersection with US 50. North of the intersection, the road becomes the main entrance to Martin State Forest. SR 650 heads south from the intersection but curves shortly afterward to head east-southeast. After crossing a tributary of the White River, the road ends at the entrance to the USG plant. The end sign for the road is attached to the USG plant's gate. SR 650 is an undivided two-lane road for its entire length.