Indium (111In) capromab pendetide

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Indium (111In) capromab pendetide?
Monoclonal antibody
Type Whole antibody
Source Mouse
Target prostatic carcinoma cells
Clinical data
Trade names Prostascint
Legal status
?
Identifiers
CAS number 151763-64-3 N (capromab)
148805-91-8 (pendetide)
ATC code V09IB04
ChEMBL CHEMBL1201579 N
Chemical data
Formula ?
 N (what is this?)  (verify)

Indium (111In) capromab pendetide (trade name Prostascint) is used to image the extent of prostate cancer.[1] Capromab is a mouse monoclonal antibody which recognizes prostate specific membrane antigen (PSMA) from prostate cancer cells and normal prostate tissue. It is linked to pendetide, a derivative of DTPA.[2] Pendetide acts as a chelating agent for the radionuclide indium-111. Following an intravenous injection of Prostascint, imaging is performed using single photon emission computed tomography (SPECT).[1]

Early trials with yttrium (90Y) capromab pendetide were also conducted.[3]

References[edit]

  1. ^ a b Manyak, M. J. (2008). "Indium-111 capromab pendetide in the management of recurrent prostate cancer". Expert Review of Anticancer Therapy 8 (2): 175–122. doi:10.1586/14737140.8.2.175. PMID 18279057.  edit
  2. ^ WHO Drug Information
  3. ^ Kahn, Daniel; J. Christopher Austin; Robert T. Maguire; Sara J. Miller; Jack Gerstbrein; Richard D. Williams (1999). "A Phase II Study of [90Y] Yttrium-Capromab Pendetide in the Treatment of Men with Prostate Cancer Recurrence Following Radical Prostatectomy". Cancer Biotherapy & Radiopharmaceuticals 14 (2): 99. doi:10.1089/cbr.1999.14.99.