Inferior petrosal sinus sampling
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In essence, it tests to see the source of the raised ACTH levels in a patient with Cushingoid features. The inferior petrosal sinus is where the pituitary gland drains. Therefore, a sample from here showing raised ACTH compared to the periphery suggests that it is a pituitary cause of Cushing's, i.e. Cushing's disease. In reality this test is performed following a Low dose dexamethasone suppression test. Increasingly, it is known as a gold-standard method for diagnosing Cushing's disease.
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