Innovative Medicines Initiative

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Innovative Medicines Initiative
Joint Technology Initiative on Innovative Medicines
Logo Innovative Medicines Initiative.jpg
Keywords Drug discovery, Drug development
Funding Agency European Commission

European Federation of Pharmaceutical Industries and Associations (EFPIA)

Project Type Joint Technology Initiative (JTI)
Reference
Objective Re-invigorate the European bio-pharmaceutical sector and to make Europe more attractive for private research and development (R&D) investment in this sector
Participants
Budget Total: 2 billion EUR

Funding: 1 billion EUR

Duration 2008 - 2017
Web Site http://imi.europa.eu

The Innovative Medicines Initiative (IMI) is a European initiative to improve the competitive situation of the European Union in the field of pharmaceutical research. The IMI is a joint initiative (public-private partnership) of the DG Research of the European Commission, representing the European Communities, and the European Federation of Pharmaceutical Industries and Associations (EFPIA). IMI is laid out as a Joint Technology Initiative within the Seventh Framework Programme.[1][2][3][4][5][6][7][8]

The Innovative Medicines Initiative is aimed towards removing research bottlenecks in the current drug development process. The IMI Joint Technology Initiative (IMI JTI), to be implemented by the IMI Joint Undertaking is meant to address these research bottlenecks. Its €2bn budget makes it the largest biomedical public-private partnership in the world.

The funding scheme has been criticised,[9] requiring universities to invest more money than with EU FP7 programs. Besides the non-competitive financial aspects of participation in IMI projects for academia, this criticism also discusses that intellectual property is freely flowing to industry.

The Sixth Framework Programme's research projects InnoMed AddNeuroMed and InnoMed PredTox acted as pilot projects establishing the feasibility of this particular public-private partnership.[10] Since then, the IMI has had four funding rounds: the first call had the topic Safety, while the second call was about Efficacy. Projects for these two calls are ongoing.[11]

The IMI 2 started in 2014 and will run until 2024, while the IMI 1 is still running. Overall budget is €3.276 billion, taken for half from the horizon 2020 program. Goals of that second calls are to improve clinical trials success rate, deliver clinical proof of concept, biomarkers and new medicines.

References[edit]

  1. ^ Hughes, V. (2008). "Europe pledges billions to solve its drug development woes". Nature Medicine 14 (2): 107. doi:10.1038/nm0208-107. PMID 18256603.  edit
  2. ^ Goldman, M. (2012). "The Innovative Medicines Initiative: A European Response to the Innovation Challenge". Clinical Pharmacology & Therapeutics 91 (3): 418–425. doi:10.1038/clpt.2011.321. PMID 22318619.  edit
  3. ^ Frima, H. J.; Gabellieri, C.; Nilsson, M. I. (2012). "Drug delivery research in the European Union's Seventh Framework Programme for Research". Journal of Controlled Release 161 (2): 409–415. doi:10.1016/j.jconrel.2012.01.044. PMID 22333557.  edit
  4. ^ Goldman, M. (2011). "Reflections on the Innovative Medicines Initiative". Nature Reviews Drug Discovery 10 (5): 321–322. doi:10.1038/nrd3434. PMID 21532547.  edit
  5. ^ Unbiased Biomarkers For The Prediction Of Respiratory Disease Outcome (u-Biopred) Consortium; Bel, E. H.; Sousa, A.; Fleming, L.; Bush, A.; Chung, K. F.; Versnel, J.; Wagener, A. H.; Wagers, S. S.; Sterk, P. J.; Compton, C. H. (2010). "Diagnosis and definition of severe refractory asthma: An international consensus statement from the Innovative Medicines Initiative (IMI)". Thorax 66 (10): 910–917. doi:10.1136/thx.2010.153643. PMID 21106547.  edit
  6. ^ Wilkinson, E. (2008). "Will the Innovative Medicines Initiative really deliver innovative medicines?". Molecular Oncology 2 (3): 203–205. doi:10.1016/j.molonc.2008.07.007. PMID 19383340.  edit
  7. ^ Kamel, N.; Compton, C.; Middelveld, R.; Higenbottam, T.; Dahlen, S. E. (2008). "The Innovative Medicines Initiative (IMI): A new opportunity for scientific collaboration between academia and industry at the European level". European Respiratory Journal 31 (5): 924–926. doi:10.1183/09031936.00033208. PMID 18448501.  edit
  8. ^ Halban, P. A. (2007). "The Innovative Medicines Initiative (IMI): A shot in the arm for European diabetes research?". Diabetologia 50 (9): 1791–1794. doi:10.1007/s00125-007-0740-y. PMID 17611733.  edit
  9. ^ Sinha, G. (2011). "Spat over Innovative Medicines Initiative (IMI) funding and intellectual property". Nature Biotechnology 29 (6): 473. doi:10.1038/nbt0611-473a. PMID 21654659.  edit
  10. ^ Reference on EFPIA's IMI site
  11. ^ Factsheets for IMI projects, IMI, 2011, accessed 17 August 2011.

External links[edit]