Inorganic Chromosome Based in Silicon

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Inchrosil Device (Picture: J.Rayon)
Figure 1 - Inchrosil's Unit
Figure 2 - Complete Circuit of Hamiltonian path problem

Inorganic Chromosome based in Silicon (InChroSil) is an electronic device designed for storage and analysis of DNA sequences, with the organization of the fundamental memory units resembling the linear nature of DNA stands. This device was developed using the standard technology Complementary metal–oxide–semiconductor (CMOS).

History[edit]

InChroSil and its systems were invented and patented in 2006 by three siblings, Silvia, Carlos and Jose Daniel Llopis at home with few economic resources.[1] The first prototype was a single nucleotide pair and was the size of a paper sheet. It was later improved into an integrated circuit in a configuration commonly referred to as a hybrid integrated circuit.

Currently prototypes are being built in the clean room of Microsystems Technology Laboratories MTL of the Massachusetts Institute of Technology.Threellop Nanotechnology Inc is the owner of the patent.

Inchrosil characteristics[edit]

InChroSil[2][3][4] permits the storage of genetic information in less space (88 percent savings), with higher performance [5][6] It can store the entire structure of the DNA (principal and secondary chains), meaning InChroSil can store and represent even incomplete chains including the existent holes within the DNA chain.

This device uses non‐volatile rewritable digital memory and is also able to store non‐genetic binary information in the nucleotides in a more compact form while retaining device, hardware and software compatibility.[7]

Adleman's experiment[edit]

Leonard Adleman's experiment computing a Hamiltonian path using DNA components,[8] was rebuilt by the Llopis siblings with inorganic electronic components. This system was intended to be less perishable than the organic materials and chemical reactions in industrial environments.

Uses for Inchrosil[edit]

Inchrosil is used mostly for mass storage of DNA sequences, with potential uses being:

  • Fingerprinting staff,[9][10] with the storage of the genetic fingerprint. His invention is Dr. Alec Jeffreys at the University of Leicester in 1984.[11]
  • Genetic studies, with the tool where large sequences would be stored, which could be compared and manipulated digitally.
  • Genebanks,[12] which store large amounts of genetic information.[13]
  • Classification of species and animals.
  • Tool medical studies (genetic).[14]

See also[edit]

References[edit]

  1. ^ Javier Carazo (2009-08-26). "Pequeños gigantes: La revolución española en el ADN". Cinco dias. 
  2. ^ Silvia, Carlos and Jose Daniel, llopis. "Electronic System to Emulate the Chain of the "DNA" Structure of a Chromosome". PCT worldwide. WIPO. Retrieved 7 November 2012. 
  3. ^ Hirsch, Cliff (November 2007). "Inchrosil - Inorganic Chromosome Based in Silicion". Semiconductor Times. 
  4. ^ Ministry of justice (Israel) (2009). "ELECTRONIC SYSTEM FOR EMULATING THE CHAIN OF THE DNA STRUCTURE OF A CHROMOSOME". Israel state scientific records. 
  5. ^ de las heras (2009-09-27). "DNI genético, identificación segura". Las provincias. 
  6. ^ belt.es, El Portal de los Profesionales de la Seguridad. (September 2009). "Threellop Nanotechnology transformará el mundo de la salud, la seguridad y la defensa". Nuevas Tecnologías Aplicadas a la Seguridad. 
  7. ^ CDTI - Centro de desarrollo tecnologico e innovación, Governamment of Spain; Ministry of Industry (Spain) (July 2009). "Innovador sistema de Almacenamiento genético electrónico". Prespectiva 31: 60. 
  8. ^ Leonard M. Adleman. Molecular Computation of solutions to combinational problems. Science, New Series, Vol. 266, No 5187, (Nov 11, 1994), 1021-1024. 
  9. ^ NanoSapin.org, Spanish Nanotechnology Network; Phantoms foundations (2009). "Threellop: Inorganic Chromosome based in Silicion". Nanoscience and nanotechnology in Spain: 168. 
  10. ^ University of Granada, Mando de Adiestramiento y Doctrina (MADOC); El Instituto Español de Estudios Estratégicos (11/12/2008). "Identification system by means of InChroSil (Inorganic Chromosome Based in Silicon)". III Congreso Internacional de Seguridad y Defensa. n III. 
  11. ^ Jeffreys A.J., Wilson V., Thein S.W. (1984). "Hypervariable 'minisatellite' regions in human DNA". Nature 314: 67–73. doi:10.1038/314067a0.
  12. ^ ANTONIO GONZÁLEZ (11/06/2007). "Tarjetas de ADN para identificar soldados". El publico. 
  13. ^ Sanchis, Eva (2009-09-20). "Ya es posible comparar el ADN de forma masiva". La Razon - Innovación. 
  14. ^ Generalitat Valenciana, Government of Spain (2008). Capacidades en Biotecnología - VIT SALUD. Valencia: Generalitat Valenciana. p. 143. 

External links[edit]