Inosine monophosphate synthase

5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
PDB rendering based on 1p4r.
Available structures PDB 1P4R, 1PKX, 1PL0
Identifiers
Symbols	ATIC; AICAR; AICARFT; FLJ93545; IMPCHASE; PURH
External IDs	OMIM: 601731 MGI: 1351352 HomoloGene: 2983 GeneCards: ATIC Gene
Gene Ontology Molecular function • IMP cyclohydrolase activity • phosphoribosylaminoimidazolecarboxamide formyltransferase activity • protein binding • transferase activity • hydrolase activity • protein homodimerization activity Cellular component • mitochondrion • cytosol Biological process • nucleobase, nucleoside, nucleotide and nucleic acid metabolic process • purine base metabolic process • purine nucleotide biosynthetic process • IMP biosynthetic process • purine ribonucleoside monophosphate biosynthetic process • organ regeneration • nucleobase, nucleoside and nucleotide metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	471	108147
Ensembl	ENSG00000138363	ENSMUSG00000026192
UniProt	P31939	Q3UTQ3
RefSeq (mRNA)	NM_004044.6	NM_026195.3
RefSeq (protein)	NP_004035.2	NP_080471.2
Location (UCSC)	Chr 2: 216.18 – 216.21 Mb	Chr 1: 71.6 – 71.63 Mb
PubMed search	[1]	[2]

Bifunctional purine biosynthesis protein PURH is a protein that in humans is encoded by the ATIC gene.

ATIC encodes an enzyme which generates inosine monophosphate from aminoimidazole carboxamide ribonucleotide.

It has two functions:

• EC 2.1.2.3 - 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase
• EC 3.5.4.10 - IMP cyclohydrolase

Further reading

• Rasmussen HH, van Damme J, Puype M et al (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis 13 (12): 960–9. doi:10.1002/elps.11501301199. PMID 1286667. 
• Yamauchi M, Seki N, Mita K et al (1996). "Isolation of human purH gene expressed in the rodent transformant cells by subtractive enrichment of 3'-untranslated region of human transcript". DNA Res. 2 (6): 269–75. doi:10.1093/dnares/2.6.269. PMID 8867801. 
• Beardsley GP, Rayl EA, Gunn K et al (1998). "Structure and functional relationships in human pur H". Adv. Exp. Med. Biol.. Advances in Experimental Medicine and Biology 431: 221–6. doi:10.1007/978-1-4615-5381-6_43. ISBN 978-0-306-45778-4. PMID 9598063. 
• Vergis JM, Bulock KG, Fleming KG, Beardsley GP (2001). "Human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase. A bifunctional protein requiring dimerization for transformylase activity but not for cyclohydrolase activity". J. Biol. Chem. 276 (11): 7727–33. doi:10.1074/jbc.M009940200. PMID 11096114. 
• Bulock KG, Beardsley GP, Anderson KS (2002). "The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). A surprising lack of substrate channeling". J. Biol. Chem. 277 (25): 22168–74. doi:10.1074/jbc.M111964200. PMID 11948179. 
• Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Cheong CG, Wolan DW, Greasley SE et al (2004). "Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates". J. Biol. Chem. 279 (17): 18034–45. doi:10.1074/jbc.M313691200. PMID 14966129. 
• Marie S, Heron B, Bitoun P et al (2004). "AICA-Ribosiduria: A Novel, Neurologically Devastating Inborn Error of Purine Biosynthesis Caused by Mutation of ATIC". Am. J. Hum. Genet. 74 (6): 1276–81. doi:10.1086/421475. PMC 1182092. PMID 15114530. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1182092. 
• Dervieux T, Furst D, Lein DO et al (2004). "Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis". Arthritis Rheum. 50 (9): 2766–74. doi:10.1002/art.20460. PMID 15457444. 
• Gerhard DS, Wagner L, Feingold EA et al (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Ewing RM, Chu P, Elisma F et al (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948. 

External links

• MeSH Inosine+monophosphate+synthase