Inosine monophosphate synthase

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5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Protein ATIC PDB 1p4r.png
PDB rendering based on 1p4r.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ATIC ; AICAR; AICARFT; HEL-S-70p; IMPCHASE; PURH
External IDs OMIM601731 MGI1351352 HomoloGene2983 ChEMBL: 2518 GeneCards: ATIC Gene
EC number 2.1.2.3, 3.5.4.10
RNA expression pattern
PBB GE ATIC 208758 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 471 108147
Ensembl ENSG00000138363 ENSMUSG00000026192
UniProt P31939 Q9CWJ9
RefSeq (mRNA) NM_004044 NM_026195
RefSeq (protein) NP_004035 NP_080471
Location (UCSC) Chr 2:
216.18 – 216.21 Mb
Chr 1:
71.56 – 71.58 Mb
PubMed search [1] [2]

Bifunctional purine biosynthesis protein PURH is a protein that in humans is encoded by the ATIC gene.[1][2][3]

ATIC encodes an enzyme which generates inosine monophosphate from aminoimidazole carboxamide ribonucleotide.

It has two functions:

  • EC 2.1.2.3 - 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase
  • EC 3.5.4.10 - IMP cyclohydrolase

References[edit]

  1. ^ Rayl EA, Moroson BA, Beardsley GP (Mar 1996). "The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping". J Biol Chem 271 (4): 2225–33. doi:10.1074/jbc.271.4.2225. PMID 8567683. 
  2. ^ Sugita T, Aya H, Ueno M, Ishizuka T, Kawashima K (Nov 1997). "Characterization of molecularly cloned human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase". J Biochem 122 (2): 309–13. doi:10.1093/oxfordjournals.jbchem.a021754. PMID 9378707. 
  3. ^ "Entrez Gene: ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase". 

Further reading[edit]

External links[edit]