Inositol monophosphatase 2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Inositol(myo)-1(or 4)-monophosphatase 2
Protein IMPA2 PDB 2czh.png
PDB rendering based on 2czh.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbol IMPA2
External IDs OMIM605922 MGI2149728 HomoloGene22799 IUPHAR: 1464 ChEMBL: 1776 GeneCards: IMPA2 Gene
EC number 3.1.3.25
Orthologs
Species Human Mouse
Entrez 3613 114663
Ensembl ENSG00000141401 ENSMUSG00000024525
UniProt O14732 Q91UZ5
RefSeq (mRNA) NM_014214 NM_053261
RefSeq (protein) NP_055029 NP_444491
Location (UCSC) Chr 18:
11.98 – 12.03 Mb
Chr 18:
67.29 – 67.32 Mb
PubMed search [1] [2]

Inositol monophosphatase 2 is a 32 kDa enzyme that in humans is encoded by the IMPA2 gene.[1][2] IMPA2 dephosphorylates myo-inositol monophosphate to myo-inositol.

The function of IMPA2 appears to be similar to IMPA1 within tissues; however, the genes are expressed differently in various tissues with IMPA2 expressed at the highest level in certain tissues of the brain and the lumen of the kidney. IMPA2 exists as a homodimer within cells and cannot form heterodimers with IMPA1.[3]

References[edit]

  1. ^ Yoshikawa T, Turner G, Esterling LE, Sanders AR, Detera-Wadleigh SD (Nov 1997). "A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder". Mol Psychiatry 2 (5): 393–97. doi:10.1038/sj.mp.4000325. PMID 9322233. 
  2. ^ "Entrez Gene: IMPA2 inositol(myo)-1(or 4)-monophosphatase 2". 
  3. ^ Ohnishi T, Ohba H, Seo KC, Im J, Sato Y, Iwayama Y, Furuichi T, Chung SK, Yoshikawa T (January 2007). "Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1". J. Biol. Chem. 282 (1): 637–46. doi:10.1074/jbc.M604474200. PMID 17068342. 

Further reading[edit]