Inositol oxygenase

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myo-inositol oxygenase
Symbol MIOX
Alt. symbols ALDRL6
Entrez 55586
HUGO 14522
OMIM 606774
RefSeq NM_017584
UniProt Q9UGB7
Other data
EC number
Locus Chr. 22 q

Inositol oxygenase is a non-heme di-iron enzyme which oxidizes myo-inositol to glucuronic acid.[1] It will also oxidize the less abundant chiro isomer of inositol.[2] This enzyme is part of the only known pathway for the catabolism of inositol in humans.[3] It is expressed mostly in the kidneys.[4][5] Depletion of Inositol Oxygenase and accumulation of polyols, such as inositol and xylitol, have been cited as contributing factors in complications associated with diabetes.[6]

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  1. ^ Bollinger JM, Jr; Diao, Y; Matthews, ML; Xing, G; Krebs, C (Feb 14, 2009). "myo-Inositol oxygenase: a radical new pathway for O(2) and C-H activation at a nonheme diiron cluster.". Dalton transactions (Cambridge, England : 2003) (6): 905–14. doi:10.1039/b811885j. PMID 19173070. 
  2. ^ Arner, R.J., Prabhu, K.S., Thompson, J.T., Hildenbrandt, G.R., Liken, A.D. and Reddy, C.C. (2001). "myo-Inositol oxygenase: molecular cloning and expression of a unique enzyme that oxidizes myo-inositol and D-chiro-inositol". Biochem. J. 360 (Pt 2): 313–320. doi:10.1042/0264-6021:3600313. PMC 1222231. PMID 11716759. 
  3. ^ Hankes, LV; Politzer, WM; Touster, O; Anderson, L (17 Oct 1969). "Myo-inositol catabolism in human pentosurics: the predominant role of the glucuronate-xylulose-pentose phosphate pathway.". Annals of the New York Academy of Sciences 165 (2): 564–76. doi:10.1111/j.1749-6632.1970.tb56424.x. PMID 5259614. 
  4. ^ Reddy, C.C., Swan, J.S. and Hamilton, G.A. (1981). "myo-Inositol oxygenase from hog kidney. I. Purification and characterization of the oxygenase and of an enzyme complex containing the oxygenase and D-glucuronate reductase". J. Biol. Chem. 256 (16): 8510–8518. PMID 7263666. 
  5. ^ Charalampous, F.C. (1959). "Biochemical studies on inositol. V. Purification and properties of the enzyme that cleaves inositol to D-glucuronic acid". J. Biol. Chem. 234 (2): 220–227. PMID 13630882. 
  6. ^ Cohen, RA; MacGregor, LC; Spokes, KC; Silva, P; Epstein, FH (October 1990). "Effect of myo-inositol on renal Na-K-ATPase in experimental diabetes.". Metabolism: clinical and experimental 39 (10): 1026–32. doi:10.1016/0026-0495(90)90161-5. PMID 2170818. 

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