Inotuzumab ozogamicin

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Inotuzumab ozogamicin ?
Monoclonal antibody
Type Whole antibody
Source Humanized (from mouse)
Target CD22
Clinical data
Legal status
CAS number 635715-01-4 N
ATC code None
KEGG D08933 YesY
Chemical data
Formula C6518H10002N1738O2036S42 
Mol. mass 150,000 Daltons
 N (what is this?)  (verify)

Inotuzumab ozogamicin (CMC-544) is an antibody-drug conjugate for the treatment of cancers.[1] It consists of the humanized monoclonal antibody inotuzumab (for CD22), linked to a cytotoxic agent from the class of calicheamicins (which is reflected by 'ozogamicin' in the drug's name).[2]

This drug is being developed by Pfizer and UCB.

It is undergoing numerous clinical trials,[3] including two phase II trials for Non-Hodgkin lymphoma (NHL).

A phase III trial in patients with follicular b-cell NHL has been terminated due to poor enrollment.[4] A Phase III trial in patients with relapsed or refractory CD22+ aggressive non-Hodgkin lymphoma (NHL) who were not candidates for intensive high-dose chemotherapy was terminated for futility.[5]

See also[edit]


  1. ^ Statement On A Nonproprietary Name Adopted By The Usan Council - Inotuzumab ozogamicin, American Medical Association.
  2. ^ Takeshita, A; Shinjo, K; Yamakage, N; Ono, T; Hirano, I; Matsui, H; Shigeno, K; Nakamura, S; Tobita, T; Maekawa, M (2009). "CMC-544 (inotuzumab ozogamicin) shows less effect on multidrug resistant cells: analyses in cell lines and cells from patients with B-cell chronic lymphocytic leukaemia and lymphoma.". British journal of haematology 146 (1): 34–43. doi:10.1111/j.1365-2141.2009.07701.x. PMID 19388933. 
  3. ^
  4. ^
  5. ^