Insulin potentiation therapy

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Insulin potentiation therapy (IPT) is an unproven alternative cancer treatment using insulin as an adjunct to low-dose chemotherapy.[1] IPT is also known as Insulin Potentiation Targeted Low Dose (IPTLD).[2] In addition to cancer, IPT has been used to treat a variety of chronic degenerative diseases.[1]


IPT was invented by Dr. Donato Perez Garcia in 1932.[3] It was developed and continued by his son, Dr. Donato Perez Garcia Bellon, as well as his grandson, Dr. Donator Perez Garcia, Jr.[3]

Originally, Garcia targeted syphilis, and later tried the treatment for chronic degenerative diseases and some types of cancer.[4]


Generally, a dose of insulin is injected into a vein, followed by a low dose of chemotherapy drugs when the insulin has been absorbed. The chemotherapy dose is usually 10% to 25% of the proven dose.[4] Then sugar water is injected to stop the hypoglycemia (low blood sugar) caused by the insulin injection.[4]


IPT has not been proven to work.[4][5] Long-term outcomes, such as survival, have never been published.[4] Four individual case studies, one small, uncontrolled clinical trial and one small prospective, randomized controlled trial have shown temporary reductions in the size of tumors for some patients.[4]

Adverse effects[edit]

The immediate risk is hypoglycemia.[4]

The use of lower than normal doses of chemotherapy can has been alleged to cause drug resistance, which could make future treatment at standard, proven doses ineffective.[4] For some cancers, especially breast and colon cancers, insulin may promote tumor growth.[4]

Mechanism of action[edit]

Two main ideas about how it might work have been proposed. The first idea is that insulin makes cells more permeable, so that the chemotherapy drugs are absorbed faster into cells. The other idea is that insulin might cause the cells to start dividing, which makes them more susceptible to destruction of many cytotoxic chemotherapy drugs.


Costs run up to US $2,000 per treatment session.[4] Multiple sessions are normal. Patients often pay the full cost out of pocket, because it is an unproven therapy that is not covered by health insurance.

Current Practice[edit]

Dr. Donato Perez Garcia, Jr. is the proprietor of US patent 4971951  for Insulin Potentiation Therapy and US patent 5155096  for the method for potentiation of a therapeutic agent.

As founder of the Academy for IPT, Dr. Donato Perez Garcia, Jr. is the only medical doctor with the legal authority to train, license, and certify other physicians in the procedure.[6]

He currently practices at Angeles Health International[7] as the Director of Functional Medicine.[8]

See also[edit]


  1. ^ a b Ayre SG, Perez Garcia y Bellon D, Perez Garcia D (1986). "Insulin potentiation therapy: a new concept in the management of chronic degenerative disease". Med. Hypotheses 20 (2): 199–210. doi:10.1016/0306-9877(86)90126-X. PMID 3526099. 
  2. ^ "History of IPT - IPTLD". IPTLD MD. Retrieved 14 May 2015. 
  3. ^ a b "History of IPT". Cancer Treatment MX. Retrieved 14 May 2015. 
  4. ^ a b c d e f g h i j "Insulin potentiation therapy". CAM-Cancer. Retrieved 2015-04-29. 
  5. ^ Wider, Barbara (17 May 2013). "What cancer care providers need to know about CAM: the CAM-Cancer project". Focus on Alternative and Complementary Therapies (Wiley). Retrieved 2015-04-29. 
  6. ^ "Certified IPT Physicians". Insulin Potentiation Therapy Alternative Cancer Treatment. Retrieved 14 May 2015. 
  7. ^ "Angeles Health International". Angeles Health International. Retrieved 14 May 2015. 
  8. ^ "Dr. Donato Perez Garcia". Angeles Health International. Retrieved 14 May 2015.