Interactive Specialization is a theory of brain development proposed by the British cognitive neuroscientist Mark Johnson, who is head of the Centre for Brain and Cognitive Development at Birkbeck, University of London, London.
In his book Developmental Cognitive Neuroscience , Johnson contrasts two views of development. According to the first, the maturational hypothesis, the relationship between structure and function (i.e. which parts of the brain perform a particular task) is static, and specific cognitive skills come “on-line” as the cortical circuitry intrinsic to a particular task matures. Johnson likens this to a "mosaic" view of development.
According to the second, the Interactive Specialization (IS)   hypothesis, development is not a unidirectional maturational process, but rather a set of complex, dynamic and back-propagated interactions between genetics, brain, body and environment. Development is not a simple question of a brain being built according to a pre-specified genetic blueprint - rather, the components of the brain are interacting with each other constantly - even prenatally, when patterns of spontaneous firing of cells in the eyes (before they have opened) transmit signals that appear to help develop the layered structure of the lateral geniculate nucleus .
The hypothesis has attracted increasing attention in recent years as a number of neuroimaging studies on younger children have provided data that appears to fit specific predictions made by Johnson's model  .
In 1996, Johnson co-authored (with Jeffrey Elman, Annette Karmiloff-Smith, Elizabeth Bates, Domenico Parisi, and Kim Plunkett), the book Rethinking Innateness  , which argues against a strong nativist (innate) view on development. Other key influences include Gilbert Gottlieb's theory of Probabilistic Epigenesis , a framework that emphasizes the reciprocity and ubiquity of gene-environment interaction in the realization of all phenotypes, and work on developmental disorders by Annette Karmiloff-Smith.
- Johnson, Mark (2005). Developmental Cognitive Neuroscience, 2nd Ed. Oxford: Blackwell Publishing. ISBN 1-4051-2629-9.
- Johnson, M.H. (2000). "Functional brain development in infants: Elements of an interactive specialization framework". Child Development 71 (1): 75–81. doi:10.1111/1467-8624.00120. PMID 10836560.
- O'Leary D.D.M, Nakagawa Y. (2002). "Patterning centers, regulatory genes and extrinsic mechanisms controlling arealization of the neocortex". Current Opinion in Neurobiology 12 (1): 14–25. doi:10.1016/S0959-4388(02)00285-4. PMID 11861160.
- Redcay E., Haist F., Courchesne E. (2008). "Paper: Functional neuroimaging of speech perception during a pivotal period in language acquisition". Developmental Science 11 (2): 237–252. doi:10.1111/j.1467-7687.2008.00674.x. PMID 18333980.
- Amso D., Casey B.J. (2006). "Paper: Beyond what develops when: neuroimaging may inform how cognition changes with development". Current Directions in Psychological Science 15 (1): 24–28. doi:10.1111/j.0963-7214.2006.00400.x.
- Elman et al., Jeffrey (1996). Rethinking Innateness: A Connectionist Perspective on Development. Cambridge, MA: MIT Press. ISBN 0-262-55030-X.
- Gottlieb, G., Lickliter, R. (2007). "FProbabilistic epigenesis". Developmental Science 10 (1): 1–11. doi:10.1111/j.1467-7687.2007.00556.x. PMID 17181692.