Interferon gamma receptor 1

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Interferon gamma receptor 1
Protein IFNGR1 PDB 1fg9.png
PDB rendering based on 1fg9.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols IFNGR1 ; CD119; IFNGR
External IDs OMIM107470 MGI107655 HomoloGene359 IUPHAR: 1725 ChEMBL: 1938 GeneCards: IFNGR1 Gene
RNA expression pattern
PBB GE IFNGR1 202727 s at tn.png
PBB GE IFNGR1 211676 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3459 15979
Ensembl ENSG00000027697 ENSMUSG00000020009
UniProt P15260 P15261
RefSeq (mRNA) NM_000416 NM_010511
RefSeq (protein) NP_000407 NP_034641
Location (UCSC) Chr 6:
137.52 – 137.54 Mb
Chr 10:
19.59 – 19.61 Mb
PubMed search [1] [2]

Interferon gamma receptor 1 (IFNGR1) also known as CD119 (Cluster of Differentiation 119), is a human gene.[1][2][3]

Function[edit]

IFNGR1 encodes the ligand-binding chain (alpha) of the heterodimeric gamma interferon receptor, which is found on macrophages. IFNGR2 encodes the non-ligand-binding partner of the heterodimeric receptor.[1]

Interactions[edit]

Interferon gamma receptor 1 has been shown to interact with Interferon-gamma.[4][5]

See also[edit]

References[edit]

  1. ^ a b "Entrez Gene: IFNGR1 interferon gamma receptor 1". 
  2. ^ Novick D, Orchansky P, Revel M, Rubinstein M (June 1987). "The human interferon-gamma receptor. Purification, characterization, and preparation of antibodies". J. Biol. Chem. 262 (18): 8483–7. PMID 2954953. 
  3. ^ Aguet M, Dembić Z, Merlin G (October 1988). "Molecular cloning and expression of the human interferon-gamma receptor". Cell 55 (2): 273–80. doi:10.1016/0092-8674(88)90050-5. PMID 2971451. 
  4. ^ Thiel, D J; le Du M H, Walter R L, D'Arcy A, Chène C, Fountoulakis M, Garotta G, Winkler F K, Ealick S E (September 2000). "Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex". Structure (ENGLAND) 8 (9): 927–36. doi:10.1016/S0969-2126(00)00184-2. ISSN 0969-2126. PMID 10986460. 
  5. ^ Kotenko, S V; Izotova L S; Pollack B P; Mariano T M; Donnelly R J; Muthukumaran G; Cook J R; Garotta G; Silvennoinen O; Ihle J N (September 1995). "Interaction between the components of the interferon gamma receptor complex". J. Biol. Chem. (UNITED STATES) 270 (36): 20915–21. doi:10.1074/jbc.270.36.20915. ISSN 0021-9258. PMID 7673114. 

Further reading[edit]

  • Samuel CE (2002). "Antiviral actions of interferons.". Clin. Microbiol. Rev. 14 (4): 778–809, table of contents. doi:10.1128/CMR.14.4.778-809.2001. PMC 89003. PMID 11585785. 
  • van Loon AP, Ozmen L, Fountoulakis M et al. (1991). "High-affinity receptor for interferon-gamma (IFN-gamma), a ubiquitous protein occurring in different molecular forms on human cells: blood monocytes and eleven different cell lines have the same IFN-gamma receptor protein.". J. Leukoc. Biol. 49 (5): 462–73. PMID 1826725. 
  • Le Coniat M, Alcaide-Loridan C, Fellous M, Berger R (1990). "Human interferon gamma receptor 1 (IFNGR1) gene maps to chromosome region 6q23-6q24.". Hum. Genet. 84 (1): 92–4. doi:10.1007/BF00210682. PMID 2532616. 
  • Novick D, Orchansky P, Revel M, Rubinstein M (1987). "The human interferon-gamma receptor. Purification, characterization, and preparation of antibodies.". J. Biol. Chem. 262 (18): 8483–7. PMID 2954953. 
  • Aguet M, Dembić Z, Merlin G (1988). "Molecular cloning and expression of the human interferon-gamma receptor.". Cell 55 (2): 273–80. doi:10.1016/0092-8674(88)90050-5. PMID 2971451. 
  • Szente BE, Subramaniam PS, Johnson HM (1996). "Identification of IFN-gamma receptor binding sites for JAK2 and enhancement of binding by IFN-gamma and its C-terminal peptide IFN-gamma(95-133).". J. Immunol. 155 (12): 5617–22. PMID 7499845. 
  • Igarashi K, Garotta G, Ozmen L et al. (1994). "Interferon-gamma induces tyrosine phosphorylation of interferon-gamma receptor and regulated association of protein tyrosine kinases, Jak1 and Jak2, with its receptor.". J. Biol. Chem. 269 (20): 14333–6. PMID 7514165. 
  • Walter MR, Windsor WT, Nagabhushan TL et al. (1995). "Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor.". Nature 376 (6537): 230–5. doi:10.1038/376230a0. PMID 7617032. 
  • Kotenko SV, Izotova LS, Pollack BP et al. (1995). "Interaction between the components of the interferon gamma receptor complex.". J. Biol. Chem. 270 (36): 20915–21. doi:10.1074/jbc.270.36.20915. PMID 7673114. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • Tjoelker LW, Seyfried CE, Eddy RL et al. (1994). "Human, mouse, and rat calnexin cDNA cloning: identification of potential calcium binding motifs and gene localization to human chromosome 5.". Biochemistry 33 (11): 3229–36. doi:10.1021/bi00177a013. PMID 8136357. 
  • Greenlund AC, Farrar MA, Viviano BL, Schreiber RD (1994). "Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91).". EMBO J. 13 (7): 1591–600. PMC 394989. PMID 8156998. 
  • Stüber D, Friedlein A, Fountoulakis M et al. (1993). "Alignment of disulfide bonds of the extracellular domain of the interferon gamma receptor and investigation of their role in biological activity.". Biochemistry 32 (9): 2423–30. doi:10.1021/bi00060a038. PMID 8443182. 
  • Dalton DK, Pitts-Meek S, Keshav S et al. (1993). "Multiple defects of immune cell function in mice with disrupted interferon-gamma genes.". Science 259 (5102): 1739–42. doi:10.1126/science.8456300. PMID 8456300. 
  • Novelli F, Giovarelli M, Gentz R et al. (1993). "Modulation of interferon-gamma receptor during human T lymphocyte alloactivation.". Eur. J. Immunol. 23 (6): 1226–31. doi:10.1002/eji.1830230605. PMID 8500521. 
  • Newport MJ, Huxley CM, Huston S et al. (1997). "A mutation in the interferon-gamma-receptor gene and susceptibility to mycobacterial infection.". N. Engl. J. Med. 335 (26): 1941–9. doi:10.1056/NEJM199612263352602. PMID 8960473. 
  • Jouanguy E, Altare F, Lamhamedi S et al. (1997). "Interferon-gamma-receptor deficiency in an infant with fatal bacille Calmette-Guérin infection.". N. Engl. J. Med. 335 (26): 1956–61. doi:10.1056/NEJM199612263352604. PMID 8960475. 
  • Gerritsma JS, Gerritsen AF, De Ley M et al. (1997). "Interferon-gamma induces biosynthesis of complement components C2, C4 and factor H by human proximal tubular epithelial cells.". Cytokine 9 (4): 276–83. doi:10.1006/cyto.1996.0164. PMID 9112336. 
  • Sogabe S, Stuart F, Henke C et al. (1998). "Neutralizing epitopes on the extracellular interferon gamma receptor (IFNgammaR) alpha-chain characterized by homolog scanning mutagenesis and X-ray crystal structure of the A6 fab-IFNgammaR1-108 complex.". J. Mol. Biol. 273 (4): 882–97. doi:10.1006/jmbi.1997.1336. PMID 9367779. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.