Interferon type III

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The recently classified type III interferon group consists of three IFN-λ (lambda) molecules called IFN-λ1, IFN-λ2 and IFN-λ3 (also called IL29, IL28A and IL28B respectively).[1] These IFNs signal through a receptor complex consisting of IL10R2 (also called CRF2-4) and IFNLR1 (also called CRF2-12). [2]

Acceptance of this classification is less universal than that of type I and type II, and unlike the other two, it is not currently included in Medical Subject Headings.


  1. ^ Vilcek J (January 2003). "Novel interferons". Nat. Immunol. 4 (1): 8–9. doi:10.1038/ni0103-8. PMID 12496969. 
  2. ^ Bartlett NW, Buttigieg K, Kotenko SV, Smith GL (June 2005). "Murine interferon lambdas (type III interferons) exhibit potent antiviral activity in vivo in a poxvirus infection model". J. Gen. Virol. 86 (Pt 6): 1589–96. doi:10.1099/vir.0.80904-0. PMID 15914836.